KCNG3
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Official Full Name
potassium voltage-gated channel, subfamily G, member 3 -
Overview
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. -
Synonyms
KCNG3;potassium voltage-gated channel, subfamily G, member 3;potassium voltage-gated channel subfamily G member 3;Kv6.3;KCNG 3;KCNG3_HUMAN;KV10.1;Kv10.1a;Kv10.1b;OTTHUMP00000201478;OTTHUMP00000201479;Potassium voltage gated channel subfamily G member 3;Voltage gated potassium channel 6.3;Voltage gated potassium channel Kv10.1;Voltage gated potassium channel subunit Kv10.1;Voltage gated potassium channel subunit Kv6.3;Voltage gated potassium channel subunit Kv6.4;Voltage-gated potassium channel subunit Kv10.1;Voltage-gated potassium channel subunit Kv6.3;OTTHUMP00000158763;OTTHUMP00000158764;voltage-gated potassium channel 6.3;voltage-gated potassium channel Kv10.1;voltage-gated potassium channel subunit Kv6.4
Recombinant Proteins
- Rhesus macaque
- Rat
- Mouse
- Human
- Mus musculus
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
KCNG3 involved in several pathways and played different roles in them. We selected most pathways KCNG3 participated on our site, such as Neuronal System,Potassium Channels,Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Voltage gated Potassium channels | KCNAB2,KCNG4A,KCNC3A,KCNA7,KCNQ3,KCNF1A,KCNC1B,KCNAB1,KCNC1A,KCNA4 |
| Potassium Channels | KCNA10,KCND2,KCNH1,KCNQ1,KCNF1,KCNC4,KCNA6,KCNK7,KCNQ2,KCNC1 |
| Neuronal System | DDX1,KCNJ1B,KCNQ1,KCNH2,HAND2,GJA10,KCNQ3,LIN7C,RAB3AA,Apba1 |
Protein Function
KCNG3 has several biochemical functions, for example, delayed rectifier potassium channel activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNG3 itself. We selected most functions KCNG3 had, and list some proteins which have the same functions with KCNG3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF460,BAZ1B,DNAJB2,FAM124A,CD300A,RPS27,EED,PPP2R3A,CSTF1,C11orf68 |
| delayed rectifier potassium channel activity | KCNV1,KCNA5,KCNS2,KCNE1,KCNC1B,KCNA6A,KCNC3A,KCNG1,KCNC1A,KCNV2 |
Interacting Protein
KCNG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNG3.
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References
- Kaminsky, Z; Jones, I; et al. DNA methylation and expression of KCNQ3 in bipolar disorder. BIPOLAR DISORDERS 17:150-159(2015).
- Hashimoto, R; Ohi, K; et al. The KCNH2 gene is associated with neurocognition and the risk of schizophrenia. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY 14:114-120(2013).
