KCNE1L
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Official Full Name
KCNE1-like -
Overview
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. This intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. -
Synonyms
KCNE1L;KCNE1-like;potassium voltage gated channel, Isk related family, member 1 like;potassium voltage-gated channel subfamily E member 1-like protein;AMMECR2 protein;AMME syndrome candidate gene 2 protein;cardiac voltage-gated potassium channel acc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNE1L-239H | Recombinant Human KCNE1L, GST-tagged | E.coli | Human | GST | 1-142aa | |
| KCNE1L-8491M | Recombinant Mouse KCNE1L Protein | Mammalian Cell | Mouse | His |
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| KCNE1L-5066HCL | Recombinant Human KCNE1L 293 Cell Lysate | HEK293 | Human | Non |
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| Kcne1l-3654M | Recombinant Mouse Kcne1l Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| KCNE1L-4727M | Recombinant Mouse KCNE1L Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KCNE1L-4727M-B | Recombinant Mouse KCNE1L Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KCNE1L involved in several pathways and played different roles in them. We selected most pathways KCNE1L participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNE1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
KCNE1L has several biochemical functions, for example, ion channel binding,potassium channel regulator activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNE1L itself. We selected most functions KCNE1L had, and list some proteins which have the same functions with KCNE1L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel binding | AP2M1,HERPUD1,RIMS1,SRC,AKAP6,AKAP9,KCNQ1,ASPH,KCNJ11,KCNIP1 |
| contributes_to voltage-gated potassium channel activity | KCNE1,KCNQ1 |
| protein binding | HIST1H4B,CHRDL2,NEFL,SMAD5,PLIN5,ZNF302,LATS2,MAGEA2,HIST1H4C,SF1 |
| contributes_to voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization | KCNH2,KCNE1 |
| potassium channel regulator activity | PRKCZ,KCNMB2,ARPP19A,DRD2,ADRB2,PIAS3,KCNMB4,SGK1,DPP10,KCNV1 |
Interacting Protein
KCNE1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNE1L here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNE1L.
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References
- Bett, GCL; Morales, MJ; et al. Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel. JOURNAL OF PHYSIOLOGY-LONDON 576:755-767(2006).
- Angelo, K; Jespersen, T; et al. KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current. BIOPHYSICAL JOURNAL 83:1997-2006(2002).
- Renieri, A; Vitelli, F; et al. KCNE1 like gene id deleted in AMME contiguous gene syndrome: identification and characterization of the human and mouse homologs.. AMERICAN JOURNAL OF HUMAN GENETICS 65:A111-A111(1999).
- Piccini, M; Vitelli, F; et al. KCNE1-like gene is deleted in AMME contiguous gene syndrome: Identification and characterization of the human and mouse homologs. GENOMICS 60:251-257(1999).
