KCNE1
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Official Full Name
potassium voltage-gated channel, Isk-related family, member 1 -
Overview
Voltage-gated potassium channels play a variety of important roles in human health and disease. KCNE1, also known as MinK, belongs to a family of small transmembrane proteins (KCNE1, -2, -3, and -4 and KCNE1L) that modulate the activity of several voltage -
Synonyms
KCNE1;potassium voltage-gated channel, Isk-related family, member 1;potassium voltage-gated channel subfamily E member 1;ISK;JLNS2;minK;minimal potassium channel;delayed rectifier potassium channel subunit IsK;voltage gated potassiun channel acces
Recombinant Proteins
- Rat
- Cynomolgus
- Mouse
- Human
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
Involved Pathway
KCNE1 involved in several pathways and played different roles in them. We selected most pathways KCNE1 participated on our site, such as Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adrenergic signaling in cardiomyocytes | CREB3L1,GNAI2A,PIK3R5,GNAS,MYL4,Adcy4,PPP1CB,VMHCL,PLCB1,ADRB2A |
Protein Function
KCNE1 has several biochemical functions, for example, delayed rectifier potassium channel activity,contributes_to delayed rectifier potassium channel activity,potassium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNE1 itself. We selected most functions KCNE1 had, and list some proteins which have the same functions with KCNE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ARAF,HOXB5,HIF1AN,MARCH5,MC5R,LC3,FOXL2,FBN1,COL10A1,EPHA2 |
| potassium channel regulator activity | AKAP9,SGK3,DPP6,ARPP19A,SGK2B,ANK2,CHP,LRRC26,KCNS3,AMIGO1 |
| contributes_to voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization | KCNH2,KCNE1L |
| delayed rectifier potassium channel activity | KCNC3A,KCNG4A,KCNQ5,KCNA10,KCNA5,KCNC1,KCNQ2A,KCNB1,KCNG2,KCNG1 |
| contributes_to delayed rectifier potassium channel activity | KCNE2,KCNQ1 |
| contributes_to voltage-gated potassium channel activity | KCNE1L,KCNQ1 |
| telethonin binding | TTN,BMP10,CSRP3,MYOZ2 |
Interacting Protein
KCNE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNE1.
KCNQ1;Tcap;CALM1;Kcnq1
Resources
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References
- Almilaji, A; Pakladok, T; et al. Upregulation of KCNQ1/KCNE1 K+ channels by Klotho. CHANNELS 8:-(2014).
- Li, J; Seyler, C; et al. Anti-KCNQ1 K channel autoantibodies increase I-Ks current and are associated with QT interval shortening in dilated cardiomyopathy. CARDIOVASCULAR RESEARCH 98:496-503(2013).
