KCNB1

  • Official Full Name

    potassium voltage-gated channel, Shab-related subfamily, member 1

  • Overview

    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.

  • Synonyms

    KCNB1;potassium voltage-gated channel, Shab-related subfamily, member 1;potassium voltage-gated channel subfamily B member 1;Kv2.1;Delayed rectifier potassium channel 1;Delayed rectifier potassium channel Kv2.1;DRK 1;DRK1;h DRK1 K(+) channel;h-DRK1;hDRK 1;hDRK1;KCB 1;KCB1;KCNB1_HUMAN;Potassium channel protein DRK1;Potassium voltage gated channel shab related subfamily member 1;Voltage-gated potassium channel subunit Kv2.1;OTTHUMP00000031697;h-DRK1 K(+) channel

Recombinant Proteins

  • Rhesus macaque
  • Rat
  • Mouse
  • Human
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc

    Involved Pathway

    KCNB1 involved in several pathways and played different roles in them. We selected most pathways KCNB1 participated on our site, such as Calcium Regulation in the Cardiac Cell,Integration of energy metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Integration of energy metabolism GNB5A,KCNS3A,MARCKSB,ARL2BP,KCNJ11,GNG13B,MARCKSA,AKAP5,RAPGEF4,SYT5
    Neuronal System NSFB,SLC6A1A,KCNMB1,KCNA2,GLS2B,KCNJ8,LIN7C,KCNG4A,SYN2,KCNK6
    Taste transduction SCNN1B,TAS2R40,TAS1R2,TAS2R144,GNG13,Adcy4,GRM4,PDE1A,GNB1,TAS2R13
    Potassium Channels KCNK18,KCNG3,KCNK7,KCNN1B,KCNAB3,KCNA1,KCNC2,KCNC1,KCNA10,KCNJ1A.2
    Calcium Regulation in the Cardiac Cell CASQ1,GJB3,PKIB,GJB2,CHRM5,CX34.4,CX27.5,GJA8,CHRM2,CX44.1
    Metabolism YAP1,ACOT9.2,TCN1,IVD,CHKA,CYP4F11,KCNJ11,ACSM1,SLC25A1,SLC25A12
    Regulation of insulin secretion MARCKSA,SYT5,ARL2,MARCKSB,KCNS3,ARL2BP,KCNS3A,KCNC2

    Protein Function

    KCNB1 has several biochemical functions, for example, delayed rectifier potassium channel activity,ion channel binding,outward rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNB1 itself. We selected most functions KCNB1 had, and list some proteins which have the same functions with KCNB1. You can find most of the proteins on our site.

    Function Related Protein
    delayed rectifier potassium channel activity KCNQ1,KCNC3B,KCNC1A,KCNA1,KCNG2,KCNQ3,KCNC3A,KCNB2,KCNA2,KCNC1
    protein binding HHIPL2,NVL,SPRR2E,GRIN2B,SUPT6H,ALKBH8,MYOD1,ERC2,MRC2,TRIM38
    ion channel binding CAV3,ACTN1,FGF12,ARRB1,SRC,KCNH5,FAM115A,EPN1,FHL1,FAM115C
    protein N-terminus binding NPAT,SYNGR3,SMARCC1,ACTN4,NCOA1,VPS25,MECP2,SLA2,NCOA3,TRP53
    outward rectifier potassium channel activity KCNK2B,KCNQ1,KCNK18,KCNK2,KCNK1A,KCNA5,KCNK5B,REST
    protein heterodimerization activity ALG2,TLR6,MYF5,SCUBE1,PHC2B,Bcl2a1b,DMRT3,TAF9,ADIPOR2,NFE2L2A
    ubiquitin-like protein binding DCUN1D3,DCUN1D1,TCHP,DCUN1D5,DCUN1D4,DCUN1D2B,DCUN1D2A,DCUN1D2

    Interacting Protein

    KCNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNB1.

    tx1_strgf

    Resources

    References

    • Vandendriessche, T; Kopljar, I; et al. Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): The first member of a new kappa-KTX subfamily. BIOCHEMICAL PHARMACOLOGY 83:1307-1317(2012).

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