KCNAB1
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Official Full Name
potassium voltage-gated channel, shaker-related subfamily, beta member 1 -
Overview
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. -
Synonyms
KCNAB1;potassium voltage-gated channel, shaker-related subfamily, beta member 1;voltage-gated potassium channel subunit beta-1;AKR6A3;hKvb3;hKvBeta3;KCNA1B;Kvb1.3;K(+) channel subunit beta-1;potassium channel beta 3 chain;potassium channel beta3
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
KCNAB1 involved in several pathways and played different roles in them. We selected most pathways KCNAB1 participated on our site, such as Neuronal System,Potassium Channels,Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Voltage gated Potassium channels | KCNA7,KCNS2,KCNAB3,KCNH1B,KCNG3,KCNA1,KCNH2A,KCNH1,KCNG4A,KCNH5A |
| Neuronal System | ARL6IP5A,CHRNA2,SLC6A11,KCNJ1A.6,KCNS3,KCNF1,KCNJ1A.1,CHRNA7,PANX1B,KCNH6A |
| metapathway biotransformation | CYP2W1,PRKRA,NAT8B,NAT9,NAA30,SULT1C2,CYP20A1,NAA40,CHST4,NAA50 |
| Potassium Channels | KCNJ1A.5,KCNQ2,KCNC4,KCNH1,KCNK2,KCNQ1,KCNJ1A.2,KCNS2,KCNJ1,KCNK13A |
Protein Function
KCNAB1 has several biochemical functions, for example, NADPH binding,aldo-keto reductase (NADP) activity,ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNAB1 itself. We selected most functions KCNAB1 had, and list some proteins which have the same functions with KCNAB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldo-keto reductase (NADP) activity | KCNAB2,H2-KE6,AKR1B10,SPR,MIOX,AKR1B1,HSD3B6,HSD11B1LA,AKR7A3,AKR1C4 |
| NADPH binding | DHFR,GRHPR,CRYZ,FASN,DECR1,CBR4,MTRR,CBR3,HMGCR,TP53I3 |
| ion channel binding | ASPH,GRINA,KCNE4,DIAP1,AASS,KCNQ1,CALM3,LRRK2,KCNE2,KCNB1 |
| potassium channel regulator activity | ANK2,ADRB2,KCNMB4,CHP,PIAS3,ABCC9,SGK2B,AMIGO1,KCNS3,SGK1 |
| voltage-gated potassium channel activity | KCNJ11,KCNH1A,KCND2,KCNV2,KCNC1B,KCNA2,HTR3A,KCNAB2,KCNC3B,KCNG4A |
Interacting Protein
KCNAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNAB1.
SRPK1;ssdna_dtdg;ARRB2
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References
- Lu, AG; Tang, Y; et al. Brain genomics of intracerebral hemorrhage. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 26:230-252(2006).
- Nakahira, K; Shi, GY; et al. Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits. JOURNAL OF BIOLOGICAL CHEMISTRY 271:7084-7089(1996).
