KCNA6
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Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 6 -
Overview
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008] -
Synonyms
KCNA6;potassium voltage-gated channel, shaker-related subfamily, member 6;HBK2;KV1.6;potassium voltage-gated channel subfamily A member 6;human brain potassium channel-2;voltage-gated potassium channel HBK2;voltage-gated potassium channel protein Kv1.6;voltage-gated potassium channel subunit Kv1.6
Recombinant Proteins
- Mouse
- Human
- Rat
- Mus musculus
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNA6-8476M | Recombinant Mouse KCNA6 Protein | Mammalian Cell | Mouse | His |
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| KCNA6-353HCL | Recombinant Human KCNA6 lysate | HEK293 | Human | Non |
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| KCNA6-4719M | Recombinant Mouse KCNA6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KCNA6-4719M-B | Recombinant Mouse KCNA6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| RFL13064RF | Recombinant Full Length Rat Potassium Voltage-Gated Channel Subfamily A Member 6(Kcna6) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length (1-530) |
|
| RFL31838HF | Recombinant Full Length Human Potassium Voltage-Gated Channel Subfamily A Member 6(Kcna6) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-529) |
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| RFL6983MF | Recombinant Full Length Mouse Potassium Voltage-Gated Channel Subfamily A Member 6(Kcna6) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-529) |
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Involved Pathway
KCNA6 involved in several pathways and played different roles in them. We selected most pathways KCNA6 participated on our site, such as Metabolism of proteins,Neuronal System,O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| O-linked glycosylation | B3GNT2A,B3GALTL,ADAMTS5,MUC21,A4GNT,SSPO,ADAMTSL3,MUC20,MUC4,ADAMTS15 |
| Metabolism of proteins | TRAPPC4,IGFBP6B,DDIT3,GPR119,HSCB,NAPAB,APCS,TBCA,MTX2,SLC25A12 |
| Voltage gated Potassium channels | KCNC3A,KCNH6A,KCNC4,KCNQ2A,KCNAB2B,KCNS3,KCNH6,KCNS2,KCNF1A,KCNH8 |
| Potassium Channels | KCNN2,KCNJ8,KCNK13B,KCNK1B,KCND3,KCNS3A,KCNA2,KCNA7,KCNH1B,KCNF1A |
| O-linked glycosylation of mucins | GALNT13,MUC15,B3GNT8,GALNTL2,A4GNT,MUC13,ST6GALNAC2,MUC1,GALNT5,MUCL1 |
| Neuronal System | GABRR2A,RAB3AA,HAND2,KCNG3,KCNAB2,KCNA2B,KCNC4,KCNA7,SLC17A7A,CHRNA2 |
| Post-translational protein modification | ARSD,CNIH2,NSMCE2,ARSH,NANP,MUC12,EIF5A2,GALNTL2,MAN1B1,ADAMTSL4 |
Protein Function
KCNA6 has several biochemical functions, for example, delayed rectifier potassium channel activity,voltage-gated potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNA6 itself. We selected most functions KCNA6 had, and list some proteins which have the same functions with KCNA6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| delayed rectifier potassium channel activity | KCNG1,KCNC1,KCNS2,KCNB1,KCNS3A,KCNH1,KCNV1,KCNC3B,KCNQ4,KCNF1A |
| voltage-gated potassium channel activity | KCNAB1,KCNH5A,KCNA4,KCNF1A,KCND2,HTR3A,KCNAB2,KCNMA1,KCNC3B,KCNT1 |
Interacting Protein
KCNA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNA6.
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