KCNA3
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Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 3 -
Overview
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. -
Synonyms
KCNA3;potassium voltage-gated channel, shaker-related subfamily, member 3;potassium voltage-gated channel subfamily A member 3;HLK3;HPCN3;Kv1.3;MK3;potassium channel 3;type n potassium channel;voltage-gated K(+) channel HuKIII;voltage-gated potassium channel protein Kv1.3;voltage-gated potassium channel subunit Kv1.3;HGK5;PCN3;HUKIII
Recombinant Proteins
- Chicken
- Rhesus macaque
- Human
- Rat
- Mouse
- Mus musculus
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
Involved Pathway
KCNA3 involved in several pathways and played different roles in them. We selected most pathways KCNA3 participated on our site, such as ATF-2 transcription factor network,ATF4 activates genes,ATF6-alpha activates chaperone genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ATF-2 transcription factor network | JUND,ATF2,DUSP5,GADD45A,POU2F1,DUSP1,KAT5,DUSP10,DDIT3,CBFB |
| ATF4 activates genes | EXOSC8,DCP2,DDIT3 |
| MAPK signaling pathway | HSPA1A,HRASB,SRFA,FGFR3,MAPK8A,MAPK14B,CACNB3A,RAC1A,CACNB2,IKBKG |
| ATF6-alpha activates chaperone genes | DDIT3 |
| Adipogenesis | FRZB,GATA2,AHR,CEBPA,NR1H3,MBNL1,CFD,SMAD3B,BMP3,KLF5 |
| ATF6-alpha activates chaperones | DDIT3,YY2 |
| Metabolism of proteins | OTOP2,PAPPAB,YIF1A,CTSH,EIF5A2,CPE,TFG,SEC23IP,ARSK,NOP56 |
| Non-alcoholic fatty liver disease (NAFLD) | COX7B,COX7B2,IL6,NR1H3,DDIT3,PRKAA1,IRS2,MAP3K11,PIK3CD,COX4I2 |
Protein Function
KCNA3 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,cAMP response element binding protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNA3 itself. We selected most functions KCNA3 had, and list some proteins which have the same functions with KCNA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cAMP response element binding protein binding | CRTC3,CRTC2,DDIT3,CRTC1,CREB3,CRTC1A,ATF2,DAPK3,CREM |
| transcription factor binding | JUND,KCTD1,STK4,DDIT3,IRF4,NAAA,NKX3-1,PSMC5,GPX3,DNMT1 |
| leucine zipper domain binding | CRX,DDIT3,PAWR,ERC1,PMF1,ATF4,AATF,NRL,DAPK3,MKL1 |
| transcription corepressor activity | TLE2,KCTD1,HDAC9,LOXL2,SIAH2,SSX2,ZHX2,NSD1,TLE4,ALX1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | PAX5,SOX1,FOXJ1,CC2D1A,GZF1,NPAS4,KLF17,HHEX,ZIC1,FOXA2 |
| protein heterodimerization activity | CREB3L3,H2-AA,TAF8,BAX,SYT16,VOX,SOX8,TAF9,HIST1H4G,TLR6 |
| transcription regulatory region sequence-specific DNA binding | NR5A2,SUV39H2,MEF2CA,ARNTL,CREB3L3,ATF3,SOX4,EGR1,PSPC1,BAHD1 |
| DNA binding | ZNF518A,RABGEF1,SIX6B,POLE4,GON4L,POU3F2A,FBXL19,ANO9A,RX1,NR5A1B |
| NOT protein homodimerization activity | NUDT16L1,MECOM,MSH3,MLXIPL,DDIT3,EXT2,MYO9B,MSH6 |
Interacting Protein
KCNA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNA3.
Dlg4
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References
- Almilaji, A; Honisch, S; et al. Regulation of the Voltage Gated K+ Channel K-v1.3 by Recombinant Human Klotho Protein. KIDNEY & BLOOD PRESSURE RESEARCH 39:609-622(2014).
