KALRN

  • Official Full Name

    kalirin, RhoGEF kinase

  • Overview

    Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described.

  • Synonyms

    KALRN;kalirin, RhoGEF kinase;HAPIP, huntingtin associated protein interacting protein (duo);kalirin;ARHGEF24;DUET;duo;Hs.8004;serine/threonine kinase with Dbl and pleckstrin homology domains;TRAD;huntingtin-associated protein interacti
Cat.# Product name Source (Host) Species Tag Protein Length Price
KALRN-3150R Recombinant Rat KALRN Protein Mammalian Cells Rat His
KALRN-8442M Recombinant Mouse KALRN Protein Mammalian Cells Mouse His
KALRN-2806R Recombinant Rat KALRN Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
KALRN-2806R-B Recombinant Rat KALRN Protein Pre-coupled Magnetic Beads HEK293 Rat
KALRN-4696M Recombinant Mouse KALRN Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
KALRN-4696M-B Recombinant Mouse KALRN Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    KALRN involved in several pathways and played different roles in them. We selected most pathways KALRN participated on our site, such as Axon guidance,Cell death signalling via NRAGE, NRIF and NADE,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KALRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    G alpha (12/13) signalling events FGD4,FGD2,ARHGEF18A,AKAP13,OBSCN,ARHGEF16,ADRA1D,GNA13,PLEKHG2,ITSN1
    EPH-Ephrin signaling ACTR2,ARPC1B,EPHA10,ARPC5,KDR,CLTC,MYL9,EFNA1,EPHB3A,EFNA3B
    EPHB-mediated forward signaling EFNB3,EFNB1,ACTR3,EFNB3B,ARPC4,EPHB4A,ARPC3,EFNB2A,ARPC1A,EFNB2
    G alpha (q) signalling events QRFP,UTS2D,TRPC6A,DGKA,FPR-RS4,APPA,PRKCHB,ANXA1A,NPFF,NPSR1
    GPCR downstream signaling SST,RHOB,CCR7,PENKB,FPR-RS6,CCR6,NET1,RGR,OXER1,EDNRAB
    Cell death signalling via NRAGE, NRIF and NADE ITSN1,ARHGEF17,PLEKHG2,FGD4,ARHGAP4A,ARHGEF9,CASP2,ARHGEF18A,TRIO,ARHGAP4
    Developmental Biology UNC5D,PSPN,SCN9A,ITSN1,SEMA3AA,KCNQ2,EFNA3B,DUSP10,NRP1A,CDH4
    Axon guidance EZRA,NCAN,COL6A2,KCNQ3,NRAS,KIF4A,RHOB,SEMA3E,SEMA6C,CDK5

    Protein Function

    KALRN has several biochemical functions, for example, ATP binding,Rho guanyl-nucleotide exchange factor activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KALRN itself. We selected most functions KALRN had, and list some proteins which have the same functions with KALRN. You can find most of the proteins on our site.

    Function Related Protein
    kinase activity MAPK14A,GKUP,PKZ,ACVR2AA,PDXKB,LIMK1A,LRRK2,PRKACAA,CDK14,RPS6KAL
    protein serine/threonine kinase activity PLK4,STK30,OXSR1B,ACVR1B,PRKCBA,ULK3,AKT2,TGFBR1,PHKG2,LMTK3
    guanyl-nucleotide exchange factor activity ARHGEF7B,SH2D3A,RIC8,RASGEF1BA,RALGDS,ARHGEF11,TRIOA,RAPGEF3,ARHGEF7,ITSN1
    Rho guanyl-nucleotide exchange factor activity RASGRF2B,ARHGEF7,TRIOA,DNMBP,ITSN2B,ARHGEF10L,ARHGEF9B,SOS1,ARHGEF3,ARHGEF7B
    transferase activity SULT1ST3,AKT2L,GSBP9,DYRK1AA,SETD1BA,UGT2B5,BMPR2B,GGACT.2,B3GALTLB,MOB1BA
    nucleotide binding CLCN3,LMTK2,MAPK12B,PET112L,ATP1A1B,ATAD1A,CKMB,PABPC4,CELF5A,ZNF638
    metal ion binding ZFP553,MB21D1,ZNF136,NEK5,TTC4,GTPBP8,DUS3L,PVALB3,MICALL2,STK25
    ATP binding TOR1A,ABCA5,DARS2,CDK17,STK19,ABCB7,PEX1,PFKMA,UCK1,ACSS1
    protein kinase activity PDK1,MAP4K1,KITB,PKN1,CAMKV,DYRK1B,IKBKAP,SRC,PHKG1B,CDK7

    Interacting Protein

    KALRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KALRN here. Most of them are supplied by our site. Hope this information will be useful for your research of KALRN.

    HAP1;Sncaip;Grin1;Grin2b;Dlg4;Ywhab

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