ITPR3
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Official Full Name
inositol 1,4,5-trisphosphate receptor, type 3 -
Overview
Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. IP3R functions as a Ca2+ release channel for intracellular stores of calcium i -
Synonyms
ITPR3;inositol 1,4,5-trisphosphate receptor, type 3;inositol 1,4,5 triphosphate receptor, type 3;inositol 1,4,5-trisphosphate receptor type 3;IP3R3;insP3R3;IP3 receptor;type 3 InsP3 receptor;inositol 1,4,5-triphosphate receptor, type 3;IP3R;FLJ3
Recombinant Proteins
- Rat
- Zebrafish
- Mouse
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ITPR3-3127R | Recombinant Rat ITPR3 Protein | Mammalian Cells | Rat | His |
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| ITPR3-6830Z | Recombinant Zebrafish ITPR3 | Mammalian Cells | Zebrafish | His |
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| ITPR3-8391M | Recombinant Mouse ITPR3 Protein | Mammalian Cells | Mouse | His |
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| ITPR3-1701H | Recombinant Human ITPR3 Protein, His&GST-tagged | E.coli | Human | GST&His | Phe2389-Asp2496 |
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| ITPR3-2783R | Recombinant Rat ITPR3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| ITPR3-2783R-B | Recombinant Rat ITPR3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ITPR3-4656M | Recombinant Mouse ITPR3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| ITPR3-4656M-B | Recombinant Mouse ITPR3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ITPR3 involved in several pathways and played different roles in them. We selected most pathways ITPR3 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone synthesis | GPX5,PRKACB,PAX8,PLCB1,TTF2,GPX7,Adcy4,PRKACG,DUOX2,ATP1A3 |
| Salivary secretion | CD38,NOS1,PRB1,PMAP-36,PLCB4,ATP2B4,CALML5,LYZ2,PLCB2,PRH2 |
| Oocyte meiosis | CALM4,PPP2CB,BUB1,CUL1A,CDC23,CAMK2G1,PRKACAA,REC8,YWHAG1,CPEB3 |
| Glutamatergic synapse | MAPK3,PRKACA,GNG2,GNGT1,PPP3R1,GLS,GRIN3A,PRKACB,GNG3,GRIA1 |
| Oxytocin signaling pathway | GNAS,PIK3CA,HRAS,MYLK4,PLCB4,PPP3CB,GNAI2,PIK3CG,OXT,PRKACG |
| GnRH signaling pathway | PRKACA,MMP2,PTK2B,MAP2K2A,CALM1A,FSHB,CACNA1SA,RAF1A,PLA2G4A,PLD1 |
| Vascular smooth muscle contraction | CALD1,PPP1R14AA,AVPR1B,MYL6,CALML3,PPP1CA,PLCB3,PLA2G10,MYL12.1,ACTG2 |
| Pancreatic secretion | RHOA,RAB11A,CLCA5,SLC4A4,CELA3B,PLA2G2E,ATP1A4,SLC26A3,LOC780933,PLA2G2F |
| Alzheimers disease | UQCRFS1,APP,PLCB4,PLCB1,CALM4,GAPDH,NDUFA13,GRIN1,NDUFC2-KCTD14,GRIN2D |
Protein Function
ITPR3 has several biochemical functions, for example, calcium channel activity,calcium ion binding,inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR3 itself. We selected most functions ITPR3 had, and list some proteins which have the same functions with ITPR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ITGB4,MMP20,BCAS2,FGF19,SLC35A2,TBX18,PPP3CB,H2AFX,SYT4,TSC2 |
| phosphatidylinositol binding | HS1BP3,TULP4A,PIK3C2G,SNX9B,PLD2,FCHO2,TNFAIP8L3,SEPT12,TULP3,PLD1A |
| intracellular ligand-gated calcium channel activity | RYR2,TRPA1,ITPR1,AKR1C1 |
| ion channel activity | TRPN1,GRIA2A,TRPA1B,FXYD6L,KCNQ2A,KCNA2B,SCN11A,CLCNK,KCNK3,TRPM1 |
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | ITPR2,ITPR1,AKR1C1 |
| calcium ion binding | RHBDL3,EPDL1,PCDH2AB8,FBN2B,AMY2A,ANXA5,LRP1,PCDH10B,VCANB,ATP2A2 |
| inositol hexakisphosphate binding | AKR1C1 |
| inositol 1,3,4,5 tetrakisphosphate binding | ADAP1,AKR1C1,ADAP2,SYT2 |
| calcium channel activity | GRIN2A,TRPV5,PKD1,MCU,P2RX1,TRPC2B,CACNA1SA,TRPM1,SLC24A5,CACNA1BA |
Interacting Protein
ITPR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR3.
Abcf1;Lrmp
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References
- MARANTO, AR; et al. PRIMARY STRUCTURE, LIGAND-BINDING, AND LOCALIZATION OF THE HUMAN TYPE-3 INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR EXPRESSED IN INTESTINAL EPITHELIUM. JOURNAL OF BIOLOGICAL CHEMISTRY 269:1222-1230(1994).
