ITPR2
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Official Full Name
inositol 1,4,5-trisphosphate receptor, type 2 -
Synonyms
ITPR2;inositol 1,4,5-trisphosphate receptor, type 2;inositol 1,4,5 triphosphate receptor, type 2;inositol 1,4,5-trisphosphate receptor type 2;IP3R2;4;5-trisphosphate receptor;Inositol 1 4 5 trisphosphate receptor type 2;Inositol 145 trisphosphate receptor type 2;InsP3 R2;InsP3R2;IP3 R2;IP3 receptor isoform 2;IP3R 2;ITPR 2;ITPR2_HUMAN;Type 2 inositol 1 4 5 trisphosphate receptor;Type 2 inositol 1;Type 2 inositol 145 trisphosphate receptor;Type 2 InsP3 receptor;IP3 receptor;inositol 1,4,5-triphosphate receptor, type 2;type 2 inositol 1,4,5-trisphosphate receptor
Recombinant Proteins
- Rat
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ITPR2-3126R | Recombinant Rat ITPR2 Protein | Mammalian Cells | Rat | His |
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| ITPR2-463H | Recombinant Human ITPR2 | Mammalian Cells | Human | His |
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| ITPR2-2347H | Recombinant Human ITPR2 Protein, His-tagged | E.coli | Human | His | Met1-Val287 |
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| ITPR2-2782R | Recombinant Rat ITPR2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| ITPR2-2782R-B | Recombinant Rat ITPR2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ITPR2-3180H | Recombinant Human ITPR2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| ITPR2-3180H-B | Recombinant Human ITPR2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
ITPR2 involved in several pathways and played different roles in them. We selected most pathways ITPR2 participated on our site, such as Adaptive Immune System,Aldosterone synthesis and secretion,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | SNCA,PSENEN,BACE1,COX4I2,FAS,NDUFS6,ATP5C1,COX4I1,UQCRFS1,CHP |
| Adaptive Immune System | TRIM41,MGC174857,KLRB1A,RNF182,NRG4,ASB6,ASB13,PDPK1A,RAPGEF4,SEC61B |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | STIM1B,IGKC,BLK,IGKV1-5,IGLC2,AHCYL1,IGHM,AKR1C1,SRMS,PIK3AP1 |
| B Cell Receptor Signaling Pathway | PIK3CB,IKBKG,CD19,PIK3CG,GSK3AB,FOS,NEDD9,CARD11,KRAS,Cd79a |
| Beta-catenin independent WNT signaling | PRICKLE1,AP2A1,PRICKLE1B,RYK,AGO2,AGO3,AGO1,DVL2,CTNNB2,GNB5 |
| Aldosterone synthesis and secretion | ADCY3,NETO2,CALM1,PLCB3,PRKCA,CAMK2A,HSD3B6,LIPE,CALML5,ATF6B |
| C-type lectin receptors (CLRs) | TAB1,CLEC4A,CLEC4D,MALT1,AHCYL1,CREBBP,IL1B2,UBE2V1,CASP8L1,CLEC6A |
Protein Function
ITPR2 has several biochemical functions, for example, calcium ion transmembrane transporter activity,inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity,phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR2 itself. We selected most functions ITPR2 had, and list some proteins which have the same functions with ITPR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | AKR1C1,ITPR3,ITPR1 |
| phosphatidylinositol binding | SH3PXD2AA,SNX5,HIP1,AKR1C1,SNX10B,TULP2,SEPT12,MYO1E,SNX17,PIK3C2A |
Interacting Protein
ITPR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR2.
TRPC4;q81ye8_bacan;MYH9;CAPZA2;NUP107;Lima1;Myo1c;Sumo3
Resources
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References
- Zhang, ZJ; Tian, JL; et al. The Analysis of Expression of CCK and IP3 Receptors in Gallstones Patients with Type 2 Diabetes Mellitus. HEPATO-GASTROENTEROLOGY 61:2173-2176(2014).
- Wang, JB; Wang, DL; et al. Tumor necrosis factor-alpha-induced reduction of glomerular filtration rate in rats with fulminant hepatic failure. LABORATORY INVESTIGATION 94:740-751(2014).
