ITPKC
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Official Full Name
inositol-trisphosphate 3-kinase C -
Overview
This gene encodes a member of the inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) 3-kinase family of enzymes that;catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is;localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide;polymorphisms in this gene are associated with Kawasaki disease. -
Synonyms
ITPKC;inositol-trisphosphate 3-kinase C;inositol 1,4,5 trisphosphate 3 kinase C;IP3 3KC;IP3KC;Inositol trisphosphate 3 kinase C;InsP 3 kinase C;IP3K C;IP3 3-kinase C;insP 3-kinase C;inositol 1,4,5-trisphosphate 3-kinase C;IP3-3KC
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
ITPKC involved in several pathways and played different roles in them. We selected most pathways ITPKC participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | IP6K2,PIK3CG,INPP4AB,DGKD,PRKCB,MTMR7B,PLCE1,PLCD3,ITPR3,PLCB4 |
| Calcium signaling pathway | EDNRA,P2RX8,TNNC1A,CALML3,SPHK2,TBXA2R,TACR3,NTSR1,HTR7,ERBB4A |
| Inositol phosphate metabolism | PIP5K1BB,INPPL1,INPPL1A,INPP4A,MTMR2,MTMR7A,PTENA,ITPK1A,NUDT3B,PLCB1 |
| Metabolic pathways | IMPDH2,GLULC,A4GALT,TPH1A,PIGX,GALNT18,NT5C3L,URAH,PGAM1A,MTHFD1 |
Protein Function
ITPKC has several biochemical functions, for example, ATP binding,calmodulin binding,inositol-1,4,5-trisphosphate 3-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKC itself. We selected most functions ITPKC had, and list some proteins which have the same functions with ITPKC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | MAP6,CAMK4,RGS16,PHKG1A,MKNK2A,ATP2B4,KCNQ1,CAMK2G,PHKG1,C2orf62 |
| inositol-1,4,5-trisphosphate 3-kinase activity | IP6K1,ITPKB,IPMKB,IP6K3,IPMK,ITPKA,IP6K2 |
| ATP binding | NEK11,P2RX3B,RIOK2,ERCC3,GPHN,MAPK8A,HSP90B1,MAP3K6,TNK2B,PANK1B |
Interacting Protein
ITPKC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKC here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKC.
PPP3CC
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References
- Rowley, AH; et al. Kawasaki Disease: Novel Insights into Etiology and Genetic Susceptibility. ANNUAL REVIEW OF MEDICINE, VOL 62, 2011 62:69-77(2011).
