ITIH2
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Official Full Name
inter-alpha-trypsin inhibitor heavy chain 2 -
Overview
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors;involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple;proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 (PubMed;2446322); Himmelfarb et al., 2004 (PubMed 14744536)). -
Synonyms
ITIH2;inter-alpha-trypsin inhibitor heavy chain 2;inter alpha (globulin) inhibitor, H2 polypeptide;inter-alpha-trypsin inhibitor heavy chain H2;H2P;Inter alpha globulin inhibitor H2 polypeptide;ITI HC2;OTTMUSP00000012019;AI747202;IGHEP2;Inter alpha (globulin) inhibitor H2;Inter alpha trypsin inhibitor complex component II;Inter alpha trypsin inhibitor heavy chain H2;Inter-alpha-inhibitor heavy chain 2;Inter-alpha-trypsin inhibitor complex component II;Intin2;ITI heavy chain H2;ITI-HC2;Itih 2;ITIH2_HUMAN;OTTHUMP00000019058;OTTHUMP00000019059;RP23 119N4.3;Serum derived hyaluronan associated protein;Serum-derived hyaluronan-associated protein;SHAP;inter-alpha (globulin) inhibitor H2;inter-alpha (globulin) inhibitor, H2 polypeptide
Recombinant Proteins
- Zebrafish
- Chicken
- Human
- Mouse
- Bovine
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Flag
- His&Fc&Avi
- His&T7
- Myc&DDK
- His&KSI
- His&Myc
Involved Pathway
ITIH2 involved in several pathways and played different roles in them. We selected most pathways ITIH2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ITIH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ITIH2 has several biochemical functions, for example, endopeptidase inhibitor activity,serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITIH2 itself. We selected most functions ITIH2 had, and list some proteins which have the same functions with ITIH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase inhibitor activity | Hc,MUG2,SERPINA1D,C5,CST14B.1,C4A,SPINK2,STFA2,LPA,STFA1 |
| serine-type endopeptidase inhibitor activity | WFDC6A,APP,SERPINA11,APLP2,SERPINB4,SERPINH2,WFIKKN2,SPINT1B,SERPINB13,WFIKKN1 |
Interacting Protein
ITIH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITIH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITIH2.
ATP5C1;d-mannose
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References
- Lin, BY; White, JT; et al. Deep depletion of abundant serum proteins reveals low-abundant proteins as potential biomarkers for human ovarian cancer. PROTEOMICS CLINICAL APPLICATIONS 3:853-861(2009).
- Veeck, J; Chorovicer, M; et al. The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylation. ONCOGENE 27:865-876(2008).
