ITGB6
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Official Full Name
Integrin, Beta 6 -
Overview
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. -
Synonyms
ITGB6;integrin, beta 6;OTTHUMP000001628962;OTTHUMP00000205127;OTTHUMP00000205128;OTTHUMP000002073332
Recombinant Proteins
- Human
- Rat
- Bovine
- Mouse
- Guinea pig
- HEK293
- E.coli
- Wheat Germ
- Mammalian Cells
- Insect Cells
- In Vitro Cell Free System
- His
- Non
- Strep
- His&Fc&Avi
- GST
- Myc&DDK
Involved Pathway
ITGB6 involved in several pathways and played different roles in them. We selected most pathways ITGB6 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dilated cardiomyopathy | Itga10&Itgb1,SGCG,ITGA2B,CACNB2,ITGA3,TPM3,ITGB7,ITGA4,CACNA2D1,SGCB |
| ECM-receptor interaction | ITGA8,CD36,CD47,LAMA1,LAMB1,GP6,COL2A1B,SDC4,COL5A1,THBS2 |
| Focal adhesion | MYLPFB,MYL2,PAK2A,THBS3A,MAPK8B,BCAR1,ITGB5,PAK6,ARHGAP35,ROCK1 |
| Hypertrophic cardiomyopathy (HCM) | ITGA8,ITGB8,CACNB1,Itga10&Itgb1,CACNA2D3,CACNG3,ITGA7,TPM3,ITGB5,LAMA2 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA10,LAMA2,ACTN3,AASS,CACNG4,ACTN4,ACTB,SGCD,CTNNA2,CACNA2D1 |
| Regulation of Actin Cytoskeleton | WASB,ITGA7,PPP1CAA,PAK1,ITGA11A,FGF8,PPP1CB,PPP1CBL,PIP5KL1,PPP1R12C |
| PIK-Akt signaling pathway | IL7R,NGF,CREB3L2,PPP2R2B,PPP2R1A,COL24A1,ANGPT4,COL6A6,GNG4,PDGFC |
Protein Function
ITGB6 has several biochemical functions, for example, integrin binding,virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB6 itself. We selected most functions ITGB6 had, and list some proteins which have the same functions with ITGB6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | P4HB,CIB2,JAM3,ADAM22,ANXA7,PPAP2B,TLN1,ICAM3,EMP2,WISP3 |
| virus receptor activity | ITGB1,HYAL2,HAVCR1,ANPEP,IDE,ACE2,RPSA,SLAMF1,EFNB3,SIVA1 |
Interacting Protein
ITGB6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB6.
Resources
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References
- Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
- Moore, KM; Thomas, GJ; et al. Therapeutic Targeting of Integrin alpha v beta 6 in Breast Cancer. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 106:-(2014).
