ITGB4
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Official Full Name
integrin, beta 4 -
Overview
CD104 is a 205 kD type I transmembrane glycoprotein, known as integrin beta4 chain or beta4 integrin, that associates with integrin alpha6 (CD49f) forms alpha6/beta4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the prol -
Synonyms
ITGB4;integrin, beta 4;integrin beta-4;CD104;GP150;CD104 antigen;integrin beta-4 subunit
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- GST
- His
- His&T7
- Myc&DDK
- His&SUMO
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
ITGB4 involved in several pathways and played different roles in them. We selected most pathways ITGB4 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | FGF16,MYLK3,DIAP3,WASB,ITGA3,RAF1,ACTG1,PIP4K2A,HRASB,FGF22 |
| Hypertrophic cardiomyopathy (HCM) | ACTG1,CACNG3,ITGB8,CACNB3,ITGA3,ITGA4,ATP2A2,ITGB3,ITGA2B,DMD |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA9,DAG1,LMNA,CACNA2D4,ITGA2B,SGCD,JUP,CACNB4,AASS,ACTN1 |
| Dilated cardiomyopathy | DMD,ITGB8,ITGA6,TGFB2,ITGA1,ITGB6,ITGA4,TPM3,SLC8A1,TNNC1 |
| PIK-Akt signaling pathway | LAMA5,YWHAZ,PPP2R5B,BCL2L1,FGF7,FGFR3,TCL1B1,STK11,EIF4E1B,SOS1 |
| ECM-receptor interaction | Reln,ITGA2,ITGA9,HMMR,COL6A1,COL4A4,THBS4,ITGB1,COL5A1,TNC |
| Focal adhesion | ERBB2,RAPGEF1,RHOAD,AASS,THBS4A,TLN1,VAV1,MYLK,PARVB,ACTN3A |
Protein Function
ITGB4 has several biochemical functions, for example, G-protein coupled receptor binding,protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB4 itself. We selected most functions ITGB4 had, and list some proteins which have the same functions with ITGB4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ETV6,RSG1,LPL,TMEM182,MBIP,RCC2,RFX5,GORAB,ADAP1,RPP38 |
| G-protein coupled receptor binding | RSPO4,PACRG,PARK2,FYN,GPRC5B,PROK1,HSPA1A,HAND2,PPY,POMC |
| receptor activity | PLXNA1,CD86,ADIPOR2,KLRB1F,NCR3,RTN4RL1,TACSTD2,CD1D,GRIA4A,CNTNAP1 |
Interacting Protein
ITGB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB4.
PLEC;ITGA6;Cadm1;S1PR3;ARRDC3
Resources
Research Area
IntegrinsFocal Adhesion Proteins in VSMC
Integrins in Focal Adhesions
Basolateral Molecules
Related Services
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References
- Chen, YH; Chang, SH; et al. The mechanism for keratinocyte detaching from pH-responsive chitosan. BIOMATERIALS 35:9247-9254(2014).
- Chen, Q; Xu, R; et al. Down-Regulation of Gli Transcription Factor Leads to the Inhibition of Migration and Invasion of Ovarian Cancer Cells via Integrin beta 4-Mediated FAK Signaling. PLOS ONE 9:-(2014).
