ISWI
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Official Full Name
Imitation SWI -
Overview
ISWI is a component of the nucleosome remodeling factor complex (NURF), a protein complex that facilitates the perturbation of chromatin structure in vitro in an ATP-dependent manner. The hydrolysis of ATP during the remodeling of chromatin is likely to be mediated by ISWI, releasing inorganic phosphate. It is also a component of the ATP-utilizing chromatin assembly and remodeling factor (ACF) and of the chromatin accessibility complex (CHRAC). This subunit may serve as the energy-transducing component of chromatin-remodeling machines. -
Synonyms
ISWI;Imitation SWI;ACF;anon-EP1279744.124;CG8625;CHRAC;dCHRAC;dISWI;Dmel\CG8625;dNURF;ISW;iswi;ISWI;NURF;Nurf-140;NURF-140;p140;p140/ISWI;SWI;CG8625-PA;CG8625-PB;CG8625-PC;ISWI ATPase;Iswi-PA;Iswi-PB;Iswi-PC;imitation SW;imitation SWI;imitation switch;imitation-SWI;nucleosome remodeling factor;nucleosome remodeling factor - 140kD
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Involved Pathway
ISWI involved in several pathways and played different roles in them. We selected most pathways ISWI participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ISWI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ISWI has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ISWI itself. We selected most functions ISWI had, and list some proteins which have the same functions with ISWI. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
ISWI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISWI here. Most of them are supplied by our site. Hope this information will be useful for your research of ISWI.
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References
- Eckey, M; Kuphal, S; et al. Nucleosome Remodeler SNF2L Suppresses Cell Proliferation and Migration and Attenuates Wnt Signaling. MOLECULAR AND CELLULAR BIOLOGY 32:2359-2371(2012).
- Mohamed, MA; Greif, PA; et al. Epigenetic events, remodelling enzymes and their relationship to chromatin organization in prostatic intraepithelial neoplasia and prostatic adenocarcinoma. BJU INTERNATIONAL 99:908-915(2007).
