IRX5
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Official Full Name
iroquois homeobox 5 -
Overview
This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
IRX5;iroquois homeobox 5;iroquois-class homeodomain protein IRX-5;IRX 2a;Homeodomain protein IRX-2A;Homeodomain Protein IRXB2;Iroquois Homeobox Protein 5;IRX2A;IRX5_HUMAN;IRXB2;OTTHUMP00000164259;OTTHUMP00000164260;IRX-2a
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IRX5-8321M | Recombinant Mouse IRX5 Protein | Mammalian Cells | Mouse | His |
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| IRX5-2948H | Recombinant Human IRX5 Protein (Met1-Ile483), N-GST tagged | E.coli | Human | GST | Met1-Ile483 |
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| IRX5-4617M | Recombinant Mouse IRX5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| IRX5-4617M-B | Recombinant Mouse IRX5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| IRX5-5022H | Recombinant Human IRX5 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
IRX5 involved in several pathways and played different roles in them. We selected most pathways IRX5 participated on our site, such as miR-1 in cardiac development, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
IRX5 has several biochemical functions, for example, DNA binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRX5 itself. We selected most functions IRX5 had, and list some proteins which have the same functions with IRX5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | C19orf40,GTF2F2A,NFAT5A,UBN2B,PHC2B,FOXP1B,XRN1,ASCL1B,SOX21B,ZBTB43 |
| sequence-specific DNA binding | POU5F3,FOXI3B,ISX,ZSCAN23,GATA1A,HOXD10,FOXB1,GSX1,POU3F2A,SALL1 |
Interacting Protein
IRX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRX5.
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References
- Jung, EJ; Park, HB; et al. Genome-wide association analysis identifies quantitative trait loci for growth in a Landrace purebred population. ANIMAL GENETICS 45:442-444(2014).
- Sato, T; Kobayashi, T; et al. Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 306:H1054-H1065(2014).
