IRX3
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Official Full Name
iroquois homeobox 3 -
Overview
IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009] -
Synonyms
IRX3;iroquois homeobox 3;IRX-1;IRXB1;iroquois-class homeodomain protein IRX-3;homeodomain protein IRXB1;iroquois homeobox protein 3;iroquois-class homeodomain protein IRX-1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IRX3-8319M | Recombinant Mouse IRX3 Protein | Mammalian Cells | Mouse | His |
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| IRX3-874HCL | Recombinant Human IRX3 cell lysate | Human | Non |
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| IRX3-4615M | Recombinant Mouse IRX3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| IRX3-4615M-B | Recombinant Mouse IRX3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| IRX3-5024H | Recombinant Human IRX3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| IRX3-5751HF | Recombinant Full Length Human IRX3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 501 amino acids |
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Involved Pathway
IRX3 involved in several pathways and played different roles in them. We selected most pathways IRX3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IRX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
IRX3 has several biochemical functions, for example, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRX3 itself. We selected most functions IRX3 had, and list some proteins which have the same functions with IRX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | SIX1A,NR2F2,NKX2.7,SP5,DLX3B,SALL1A,TLX3B,FOXP3A,RXRGA,FOXJ3 |
Interacting Protein
IRX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRX3.
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References
- Juraver-Geslin, HA; Gomez-Skarmeta, JL; et al. The conserved barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog. DEVELOPMENTAL BIOLOGY 396:107-120(2014).
- Sato, T; Kobayashi, T; et al. Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 306:H1054-H1065(2014).
