IRS4
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Official Full Name
Insulin receptor substrate 4 -
Overview
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. -
Synonyms
IRS4;nsulin receptor substrate 4;pp160;phosphoprotein of 160 kDa;160 kDa phosphotyrosine protein;IRS-4;PY160
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- His&T7
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IRS4-1052H | Recombinant Human IRS4 protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Arg196 |
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| Irs4-1053M | Recombinant Mouse Irs4 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Met1~Arg299 |
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| IRS4-8316M | Recombinant Mouse IRS4 Protein | Mammalian Cell | Mouse | His |
|
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| IRS4-5157HCL | Recombinant Human IRS4 293 Cell Lysate | HEK293 | Human | Non |
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| IRS4-4612M | Recombinant Mouse IRS4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| IRS4-4612M-B | Recombinant Mouse IRS4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| IRS4-5028H | Recombinant Human IRS4 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
IRS4 involved in several pathways and played different roles in them. We selected most pathways IRS4 participated on our site, such as cGMP-PKG signaling pathway,FoxO signaling pathway,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin signaling pathway | PRKAB1B,SOCS1A,MKNK2,PTPN1,INSRA,AKT2L,MKNK2A,SOCS2,FOXO1A,PRKAR2AA |
| FoxO signaling pathway | PIK3CD,CCND1,PRKAB1A,SKP2,NLK2,G6PC,GADD45AA,PIK3R3B,FOXO1A,MAPK12B |
| Type II diabetes mellitus | MAPK9,PRKCZ,MAPK10,IRS1,SOCS3,PKM,INS1,INS,SOCS4,PDX1 |
| AMPK signaling pathway | CAMKK2,ELAVL1,PPARG,TSC1,CD36,MLYCD,SCD,PIK3R2,PPP2R5D,INS1 |
| cGMP-PKG signaling pathway | PLCB3,CALML3,ATP1A2,RAF1,ATP2A3,PPIF,SLC25A31,ATP1B3,PPP1CA,NFATC4 |
| Adipocytokine signaling pathway | RXRGB,ACSBG2,SOCS3B,CAMKK2,CAMKK1A,G6PC,PPARAB,PRKAG2A,ACSL4A,PPARGC1A |
| Regulation of lipolysis in adipocytes | AQP7,PIK3R5,IRS2,PRKACB,LOC100328615,PRKACG,NPY1R,PTGER3,PRKG2,PIK3CG |
Protein Function
IRS4 has several biochemical functions, for example, SH3/SH2 adaptor activity,insulin receptor binding,phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS4 itself. We selected most functions IRS4 had, and list some proteins which have the same functions with IRS4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol 3-kinase binding | IGF1RA,HCST,IGF1R,INSRR,CALM3,FYN,BECN1,LCK,IRS2,INSRB |
| insulin receptor binding | SNX4,IGF1R,SNX2,DOK2,SLC2A2,DOK5,INS1,IRS2,PTPN11,FRS2A |
| SH3/SH2 adaptor activity | SH2B2,TOB1,KHDRBS1,SKAP1,NCK2,PTPN11,CHN1,LASP1,ARHGAP4,EPS8 |
| signal transducer activity | MAGI2,GNAS,OLFR1002,NEK6,PLCD1B,GNGT1,CCR12A,GPR98,TAAR13C,OLFCG4 |
| protein binding | USE1,TMEM199,NKX2-1,SLC30A8,ATCAY,RPGRIP1L,STOM,TNFRSF12A,KRT6A,LOH12CR1 |
Interacting Protein
IRS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS4.
YWHAB;P;PTGES3;CRK;PPP2R2B;EGFR;ERBB2
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