IRF8
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Official Full Name
interferon regulatory factor 8 -
Overview
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory;factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region;and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the;IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha;and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced;by viral infection. -
Synonyms
IRF8;interferon regulatory factor 8;interferon consensus sequence-binding protein;interferon consensus sequence binding protein 1;Myls;ICSBP;IRF-8;Icsbp1;AI893568
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- Wheat Germ
- In Vitro Cell Free System
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
- GST
- His&SUMO
Involved Pathway
IRF8 involved in several pathways and played different roles in them. We selected most pathways IRF8 participated on our site, such as Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pertussis | ITGAM,GNAI3,CFL2,NOS2,FOS,NFKB1,Hc,C3,MAPK8,C1QC |
Protein Function
IRF8 has several biochemical functions, for example, protein binding,regulatory region DNA binding,transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF8 itself. We selected most functions IRF8 had, and list some proteins which have the same functions with IRF8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| regulatory region DNA binding | HMGA2,IRF2A,IRF4A,IRF5,IRF3,NFKB1,IRF1A,IRF1B,IRF6 |
| protein binding | KLK6,PAK1IP1,NR3C2,CDCA4,TAF1,AES,CFLAR,C1GALT1C1,EIF4A3,GPR37L1 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | PROX1,SRF,NR5A2,MEIS1,CEBPB,CEBPA,POU3F1,SRY,RFX3,SPI1 |
Interacting Protein
IRF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF8.
IRF6;flgK;q8d1m8_yerpe;MID1;CDK4;COPS2;GPS1;COPS6;COPS5;COPS4
Resources
Research Area
Apoptosis Transcription Factors and RegulatorsPlasmacytoid Dendritic Cells
Dendritic Cell Development
Related Services
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References
- Bystrom, S; Ayoglu, B; et al. Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis. JOURNAL OF PROTEOME RESEARCH 13:4607-4619(2014).
- Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).
