IPPK
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Official Full Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinase -
Overview
The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. -
Synonyms
IPPK;inositol 1,3,4,5,6-pentakisphosphate 2-kinase;C9orf12, chromosome 9 open reading frame 12;inositol-pentakisphosphate 2-kinase;FLJ13163;INSP5K2;IP5K;IPK1;3;4;5;6)P5 2-kinase;6-pentakisphosphate 2-kinase;bA476B13.1 (novel protein);C9orf12;inositol 1,3,4,5,6 pentakisphosphate 2 kinase;Inositol pentakisphosphate 2 kinase;Inositol-1;Ins;Ins(1;InsP5 2 kinase;InsP5 2-kinase;IPK1 homolog;IPPK_HUMAN;ins(1,3,4,5,6)P5 2-kinase;bA476B13.1
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IPPK-1310H | Recombinant Human IPPK Protein, GST-Tagged | Wheat Germ | Human | GST |
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| IPPK-2252Z | Recombinant Zebrafish IPPK | Mammalian Cells | Zebrafish | His |
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| IPPK-3089R | Recombinant Rat IPPK Protein | Mammalian Cells | Rat | His |
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| IPPK-5590C | Recombinant Chicken IPPK | Mammalian Cells | Chicken | His |
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| IPPK-8269M | Recombinant Mouse IPPK Protein | Mammalian Cells | Mouse | His |
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| IPPK-5181HCL | Recombinant Human IPPK 293 Cell Lysate | HEK293 | Human | Non |
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| IPPK-2745R | Recombinant Rat IPPK Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| IPPK-2745R-B | Recombinant Rat IPPK Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Ippk-3566M | Recombinant Mouse Ippk Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| IPPK-4585M | Recombinant Mouse IPPK Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| IPPK-4585M-B | Recombinant Mouse IPPK Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
IPPK involved in several pathways and played different roles in them. We selected most pathways IPPK participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IPPK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | MTMR2,IMPA2,PTEN,TMEM55A,PIP4K2C,PLCD4,MTMR1,PLCZ1,ITPKB,INPP1 |
| Metabolic pathways | CHKB,DEGS2,COQ5,MINPP1,PLA2G4F,PGD,LIPC,AUH,HAAO,DNMT4 |
| Inositol phosphate metabolism | TPI1A,PLCH1,IMPA2,PLCD3A,INPP5KA,PLCD1,TPI1B,PIP4K2AA,NUDT4,INPPL1A |
Protein Function
IPPK has several biochemical functions, for example, ATP binding,inositol pentakisphosphate 2-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IPPK itself. We selected most functions IPPK had, and list some proteins which have the same functions with IPPK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NEK12,PIP5K1C,ALK,NME2A,PAK2,PRKACAB,STK24A,DAPK2A,P2RY2,CDK13 |
Interacting Protein
IPPK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IPPK here. Most of them are supplied by our site. Hope this information will be useful for your research of IPPK.
p27958-pro_0000037566
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References
- Lee, HS; Lee, DH; et al. InsP(6)-Sensitive Variants of the Gle1 mRNA Export Factor Rescue Growth and Fertility Defects of the ipk1 Low-Phytic-Acid Mutation in Arabidopsis. PLANT CELL 27:417-431(2015).
- Kuo, HF; Chang, TY; et al. Arabidopsis inositol pentakisphosphate 2-kinase, AtIPK1, is required for growth and modulates phosphate homeostasis at the transcriptional level. PLANT JOURNAL 80:503-515(2014).
