IP6K2
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Official Full Name
Inositol Hexakisphosphate Kinase 2 -
Overview
This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
PIUS;IHPK2;IP6K2;inositol hexakisphosphate kinase 2;insp6 kinase 2;OTTHUMP00000164824;OTTHUMP00000210210;OTTHUMP00000210211;OTTHUMP00000210215;OTTHUMP00000210229;OTTHUMP00000210234;pi uptake stimulator;inositol hexaphosphate kinase 2;ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
IP6K2 involved in several pathways and played different roles in them. We selected most pathways IP6K2 participated on our site, such as Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IP6K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | IMPA1,INPP1,CALML5,PLCB3,PIK3R5,PIK3CB,PTENA,ITPKA,PLCB1,IP6K1 |
Protein Function
IP6K2 has several biochemical functions, for example, ATP binding,inositol hexakisphosphate 1-kinase activity,inositol hexakisphosphate 3-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IP6K2 itself. We selected most functions IP6K2 had, and list some proteins which have the same functions with IP6K2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | HSPA1A,MAPKAPK5,DMC1,GRK6,CIT,SMARCA4,EIF2AK4,KCNJ10,ILF2,TGFBR2 |
| inositol hexakisphosphate 3-kinase activity | IP6K3,PPIP5K1,IP6K1,PPIP5K2 |
| inositol-1,4,5-trisphosphate 3-kinase activity | IPMKB,IP6K1,IPMK,ITPKC,ITPKB,ITPKA,IP6K3 |
| protein binding | PDCD4,ERC2,SLU7,HLA-DRB4,SH3RF2,CDKAL1,FBXW8,RCN1,PXMP2,RND1 |
| inositol hexakisphosphate 5-kinase activity | IP6K1,PPIP5K2,IP6K3,PPIP5K1 |
| inositol hexakisphosphate 1-kinase activity | PPIP5K2,IP6K3,PPIP5K1,IP6K1 |
Interacting Protein
IP6K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IP6K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IP6K2.
MEOX2;RBPMS;PLSCR1;LNX2
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References
- Rao, F; Xu, J; et al. Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:1773-1778(2015).
- Wang, HC; DeRose, EF; et al. IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family. NATURE COMMUNICATIONS 5:-(2014).
