IP6K1
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Official Full Name
inositol hexakisphosphate kinase 1 -
Overview
This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. -
Synonyms
IP6K1;inositol hexakisphosphate kinase 1;IHPK1, inositol hexaphosphate kinase 1;KIAA0263;IHPK1;Inositol hexaphosphate kinase 1;InsP6;InsP6 kinase 1;Itpk6;PiUS;Pi uptake stimulator;ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- GST
- His
- SUMO
- Non
- Avi
- Fc
Involved Pathway
IP6K1 involved in several pathways and played different roles in them. We selected most pathways IP6K1 participated on our site, such as Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IP6K1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | PRKCA,PIK3CA,CALM3B,ITPR3,MTM1,PLCG1,ITPKC,PI4KB,PLCE1,PRKCG |
Protein Function
IP6K1 has several biochemical functions, for example, ATP binding,inositol hexakisphosphate 1-kinase activity,inositol hexakisphosphate 3-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IP6K1 itself. We selected most functions IP6K1 had, and list some proteins which have the same functions with IP6K1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol-1,4,5-trisphosphate 3-kinase activity | ITPKB,ITPKA,IPMK,IPMKB,ITPKC,IP6K2,IP6K3 |
| inositol hexakisphosphate 1-kinase activity | PPIP5K1,PPIP5K2,IP6K2,IP6K3 |
| ATP binding | MOV10,ANKK1,CAMK2D,MAP2K5,KIF13B,ABCB11,FGFR1,FRK,CAMK2D2,RET |
| inositol hexakisphosphate 5-kinase activity | IP6K2,PPIP5K1,IP6K3,PPIP5K2 |
| inositol hexakisphosphate 3-kinase activity | PPIP5K2,PPIP5K1,IP6K3,IP6K2 |
Interacting Protein
IP6K1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IP6K1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IP6K1.
CACNA1A;EXOSC7
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References
- Yang, SN; Shi, Y; et al. Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:12183-12188(2012).
- Nalaskowski, MM; Windhorst, S; et al. Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains. BIOLOGICAL CHEMISTRY 387:583-593(2006).
- Brailoiu, E; Miyamoto, MD; et al. Inositol derivatives modulate spontaneous transmitter release at the frog neuromuscular junction. NEUROPHARMACOLOGY 45:691-701(2003).
- Fukuda, M; Mikoshiba, K; et al. The function of inositol high polyphosphate binding proteins. BIOESSAYS 19:593-603(1997).
