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INVS

Official Full Name

inversin
Overview

This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012]
Synonyms

INVS; inversin; INV; NPH2; NPHP2; nephrocystin-2; inversion of embryonic turning; inversion of embryo turning homolog;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	INVS-395H	Recombinant Human INVS	Mammalian Cell	His		Inquiry
Human	INVS-7870H	Recombinant Human INVS protein, His & T7-tagged	E.coli	His&T7	Met1~Val237	Inquiry
Human	INVS-3165H	Recombinant Human INVS Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	INVS-5082H	Recombinant Human INVS Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	INVS-3165H-B	Recombinant Human INVS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	INVS-5686HF	Recombinant Full Length Human INVS Protein, GST-tagged	In Vitro Cell Free System	GST	101 amino acids	Inquiry
Human	INVS-3510H	Recombinant Human INVS Protein (Met1-Lys91), N-GST tagged	E.coli	GST	Met1-Lys91	Inquiry
Mouse	Invs-2331M	Recombinant Mouse Invs Protein, His-tagged	E.coli	His	Met1-Val239	Inquiry
Zebrafish	INVS-9436Z	Recombinant Zebrafish INVS	Mammalian Cell	His		Inquiry
Chicken	INVS-6120C	Recombinant Chicken INVS	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

INVS involved in several pathways and played different roles in them. We selected most pathways INVS participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INVS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Wnt signaling pathway	SKP1;WNT2BB;SOST;FBXW11;WNT10B;WNT4;CCND1;MAPK9;CAMK2D1

INVS has several biochemical functions, for example, calmodulin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INVS itself. We selected most functions INVS had, and list some proteins which have the same functions with INVS. You can find most of the proteins on our site.

Function	Related Protein
calmodulin binding	MYLK2;KCNN4;INVS;PLCB3;MARCKSL1;MYH9;PHKG1A;KCNH1;IQGAP3
protein binding	DNAJB1;PDCD5;POLRMT;ZCCHC17;PSG1;SH3RF2;FBXL5;C9orf116;SELE

INVS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INVS here. Most of them are supplied by our site. Hope this information will be useful for your research of INVS.

Research Area

Widman, DG; Frolov, I; et al. Third-Generation Flavivirus Vaccines Based on Single-Cycle, Encapsidation-Defective Viruses. ADVANCES IN VIRUS RESEARCH, VOL 72 72:77-126(2008).

SODEIK, B; DOMS, RW; et al. ASSEMBLY OF VACCINIA VIRUS - ROLE OF THE INTERMEDIATE COMPARTMENT BETWEEN THE ENDOPLASMIC-RETICULUM AND THE GOLGI STACKS. JOURNAL OF CELL BIOLOGY 121:521-541(1993).