INVS
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Official Full Name
inversin -
Overview
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012] -
Synonyms
INVS;inversin;INV;NPH2;NPHP2;nephrocystin-2;inversion of embryonic turning;inversion of embryo turning homolog
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- T7
- Avi
- Fc
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| INVS-395H | Recombinant Human INVS | Mammalian Cells | Human | His |
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| INVS-6120C | Recombinant Chicken INVS | Mammalian Cells | Chicken | His |
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| INVS-7870H | Recombinant Human INVS protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Val237 |
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| INVS-9436Z | Recombinant Zebrafish INVS | Mammalian Cells | Zebrafish | His |
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| Invs-2331M | Recombinant Mouse Invs Protein, His-tagged | E.coli | Mouse | His | Met1-Val239 |
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| INVS-3165H | Recombinant Human INVS Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| INVS-3165H-B | Recombinant Human INVS Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| INVS-3510H | Recombinant Human INVS Protein (Met1-Lys91), N-GST tagged | E.coli | Human | GST | Met1-Lys91 |
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| INVS-5082H | Recombinant Human INVS Protein, GST-tagged | Wheat Germ | Human | GST |
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| INVS-5686HF | Recombinant Full Length Human INVS Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 101 amino acids |
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Involved Pathway
INVS involved in several pathways and played different roles in them. We selected most pathways INVS participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INVS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | TCF7L2,WNT6,BAMBIB,MAPK8B,WNT9B,WNT4A,FZD3,GPC4,WNT9A,ROCK2 |
Protein Function
INVS has several biochemical functions, for example, calmodulin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INVS itself. We selected most functions INVS had, and list some proteins which have the same functions with INVS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | MKNK2,SCN5A,CAMK2D1,C2orf62,NRGN,SLC9A1,NOS3,RYR2,ENKUR,GEM |
| protein binding | TULP1,GCC2,MED20,RAB26,ICA1,IFITM3,PSMD4,CRY2,CD300LG,PIK3CB |
Interacting Protein
INVS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INVS here. Most of them are supplied by our site. Hope this information will be useful for your research of INVS.
Resources
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References
- Widman, DG; Frolov, I; et al. Third-Generation Flavivirus Vaccines Based on Single-Cycle, Encapsidation-Defective Viruses. ADVANCES IN VIRUS RESEARCH, VOL 72 72:77-126(2008).
- SODEIK, B; DOMS, RW; et al. ASSEMBLY OF VACCINIA VIRUS - ROLE OF THE INTERMEDIATE COMPARTMENT BETWEEN THE ENDOPLASMIC-RETICULUM AND THE GOLGI STACKS. JOURNAL OF CELL BIOLOGY 121:521-541(1993).
