INTS3
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Official Full Name
integrator complex subunit 3 -
Overview
INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large;subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2;(RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)). INTS3 is also a subunit of single-stranded DNA;(ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) (PubMed;19683501). -
Synonyms
INTS3;integrator complex subunit 3;C1orf60, chromosome 1 open reading frame 60;FLJ21919;INT3;C1orf193;C1orf60;INT 3;SOSS complex subunit A;RP11-216N14.4;sensor of ssDNA A;OTTHUMP00000035161;OTTHUMP00000038687;OTTHUMP00000222672;sensor of ssDNA subunit A;sensor of single-strand DNA complex subunit A;SOSS-A;RP11-216N14.2
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| INTS3-130H | Recombinant Human INTS3, His-tagged | E.coli | Human | His | 91-445aa | |
| INTS3-4033Z | Recombinant Zebrafish INTS3 | Mammalian Cells | Zebrafish | His |
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| INTS3-8247M | Recombinant Mouse INTS3 Protein | Mammalian Cells | Mouse | His |
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| INTS3-3618H | Recombinant Human INTS3 Protein (Thr641-Leu895), C-His tagged | E.coli | Human | His | Thr641-Leu895 |
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| INTS3-4567M | Recombinant Mouse INTS3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| INTS3-4567M-B | Recombinant Mouse INTS3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| INTS3-5088H | Recombinant Human INTS3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| INTS3-5672HF | Recombinant Full Length Human INTS3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 1042 amino acids |
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| Ints3-5761M | Recombinant Mouse Ints3 Protein (Thr639-Lys891), C-His tagged | E.coli | Mouse | His | Thr639-Lys891 |
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Involved Pathway
INTS3 involved in several pathways and played different roles in them. We selected most pathways INTS3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with INTS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
INTS3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INTS3 itself. We selected most functions INTS3 had, and list some proteins which have the same functions with INTS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FFAR2,TMEM27,CUTC,ASB2,MMRN2,MMACHC,ERP44,SET,RAN,FBXO27 |
Interacting Protein
INTS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INTS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of INTS3.
ZBTB14;UBA1;UBE2N;UBE2V1;NFKB1;ssdna_dadc;E2F3;p27958-pro_0000037566;SNW1;CDC5L
Resources
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References
- Skaar, JR; Ferris, AL; et al. The Integrator complex controls the termination of transcription at diverse classes of gene targets. CELL RESEARCH 25:288-305(2015).
- Stadelmayer, B; Micas, G; et al. Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes. NATURE COMMUNICATIONS 5:-(2014).
