INPP5K
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Official Full Name
inositol polyphosphate-5-phosphatase K -
Overview
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
INPP5K;inositol polyphosphate-5-phosphatase K;inositol polyphosphate 5-phosphatase K;skeletal muscle and kidney enriched inositol phosphatase;SKIP;43 kDa form skeletal muscle and kidney enriched inositol phosphatase;INP5K_HUMAN;muscle and kidney-enriched inositol phosphatase;PPS;Skeletal muscle and kidney-enriched inositol phosphatase
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- DDK
- Myc
- Avi
- Fc
- GST
Involved Pathway
INPP5K involved in several pathways and played different roles in them. We selected most pathways INPP5K participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5K were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | PIP5K1BB,PIK3R3A,IMPA2,PTENA,PIK3R1,PIK3CD,PIP4K2AA,PLCD1,INPP5E,PRKCBB |
| Metabolic pathways | PGM2,ATP6V0E1,SAT2B,CHIA.2,PTGS1,UGT2A3,FH1,ALDH7A1,GLUD1A,POLR2H |
| Insulin signaling pathway | PHKB,BADB,PRKAG3,INPPL1A,CALM4,G6PCA.1,PCK1,INPPL1,EIF4E2RS1,MAPK1 |
| Inositol phosphate metabolism | PIP4K2B,MTMR1,PTENA,MTMR1A,IPMKB,PI4K2B,INPPL1A,TPI1B,PIK3CD,PLCD3A |
Protein Function
INPP5K has several biochemical functions, for example, inositol bisphosphate phosphatase activity,inositol trisphosphate phosphatase activity,inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5K itself. We selected most functions INPP5K had, and list some proteins which have the same functions with INPP5K. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol bisphosphate phosphatase activity | PXYLP1,SACM1L,TENC1,PTPRQ,CTDSPL2A,SACM1LA,SACM1LB,CTDSPL2B,SGPP2,NT5DC3 |
| inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity | INPP5A,INPP5J |
| inositol-1,4,5-trisphosphate 5-phosphatase activity | INPP5B,INPP5A,INPP5J |
| phosphatidylinositol trisphosphate phosphatase activity | INPP4B,INPP5D |
| lipid phosphatase activity | PPAP2C,LPPR2A,LPPR5A,PPAP2A,LPPR5B,LPPR3A,PPAP2CB,PTENA,LPPR3,LPPR1 |
| protein binding | TRIM55,CD79B,IRF3,ATG5,MAP1B,JAGN1,C14orf169,C22orf29,NCKIPSD,ESYT1 |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | INPP5J |
| inositol-polyphosphate 5-phosphatase activity | INPP5J,INPP5E,INPP5D,INPPL1,INPP5A |
| phosphatidylinositol phosphate 5-phosphatase activity | SYNJ1 |
Interacting Protein
INPP5K has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5K here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5K.
MAD2L1BP;KRT31;FATE1;LNX1;PYGM;EPPK1;DCD;PDXDC1;PFDN1;TTR;TK1;HSPB1
INPP5K Related Signal Pathway
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