INPP5F
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Official Full Name
inositol polyphosphate-5-phosphatase F -
Overview
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
INPP5F;inositol polyphosphate-5-phosphatase F;phosphatidylinositide phosphatase SAC2;hSac2;KIAA0966;SAC2;cI-27;Inositol polyphosphate 5 phosphatase F;MSTP007;MSTP047;Sac domain containing inositol phosphatase 2;Sac domain-containing phosphoinositide 5-phosphatase 2;Sac domain-containing inositol phosphatase 2;MSTPO47
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| INPP5F-6735Z | Recombinant Zebrafish INPP5F | Mammalian Cells | Zebrafish | His |
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| INPP5F-863HCL | Recombinant Human INPP5F cell lysate | Human | Non |
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| Inpp5f-184M | Recombinant Mouse Inpp5f Protein, MYC/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| INPP5F-2398H | Recombinant Human INPP5F Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| INPP5F-5409H | Recombinant Human INPP5F Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
INPP5F involved in several pathways and played different roles in them. We selected most pathways INPP5F participated on our site, such as 3-phosphoinositide degradation,D-myo-inositol (1,4,5)-trisphosphate degradation,superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| 3-phosphoinositide degradation | PTPMT1 |
Protein Function
INPP5F has several biochemical functions, for example, phosphoric ester hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5F itself. We selected most functions INPP5F had, and list some proteins which have the same functions with INPP5F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphoric ester hydrolase activity | RAG1,GDPD4,SACM1L,RNASEKA,RNASEKB,ENDOU2,SMG6,EXO5,SACM1LB,ZRANB3 |
Interacting Protein
INPP5F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5F here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5F.
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References
- Montjean, R; Aoidi, R; et al. OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells. HUMAN MOLECULAR GENETICS 24:994-1006(2015).
- Kim, HS; Li, AG; et al. Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity. SCIENTIFIC REPORTS 4:-(2014).
