INPP5E
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Official Full Name
inositol polyphosphate-5-phosphatase, 72 kDa -
Overview
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. -
Synonyms
INPP5E;inositol polyphosphate-5-phosphatase, 72 kDa;JBTS1, Joubert syndrome 1;72 kDa inositol polyphosphate 5-phosphatase;CORS1;PPI5PIV;Inositol polyphosphate 5 phosphatase;Phosphatidylinositol (4,5) bisphosphate 5 phosphatase;Phosphatidylinositol polyphosphate 5 phosphatase type IV;phosphatidylinositol-4,5-bisphosphate 5-phosphatase;phosphatidylinositol (4,5) bisphosphate 5-phosphatase;phosphatidylinositol polyphosphate 5-phosphatase type IV;CPD4;JBTS1;MORMS
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- HEK293
- Wheat Germ
- E.coli
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
- GST
Involved Pathway
INPP5E involved in several pathways and played different roles in them. We selected most pathways INPP5E participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | AGPAT5,NDUFS8B,PIGH,FUT6,LALBA,SC5DL,UGP2A,GCH2,GALNT3,LPCAT4 |
| Phosphatidylinositol signaling system | PIK3R1,INPP5K,PIK3CG,PI4K2A,TMEM55B,ITPKB,PLCE1,PLCD4,PIK3R3,PIP4K2B |
| Inositol phosphate metabolism | TPI1A,PIK3CA,PLCB1,PIP4K2C,PTEN,MTMR1,MTMR6,PLCD1,CDIPT,PLCD1B |
Protein Function
INPP5E has several biochemical functions, for example, inositol-polyphosphate 5-phosphatase activity,phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5E itself. We selected most functions INPP5E had, and list some proteins which have the same functions with INPP5E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol-polyphosphate 5-phosphatase activity | INPP5A,INPP5K,INPPL1,INPP5J,INPP5D |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | INPP5B,EPM2A,SYNJ2,OCRL,PTPMT1 |
Interacting Protein
INPP5E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5E here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5E.
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References
- Kong, AM; Speed, CJ; et al. Cloning, and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network. JOURNAL OF BIOLOGICAL CHEMISTRY 275:24052-24064(2000).
- ROSS, TS; JEFFERSON, AB; et al. CLONING AND EXPRESSION OF HUMAN 7K-KDA INOSITOL POLYPHOSPHATE-5-PHOSPHATASE. JOURNAL OF BIOLOGICAL CHEMISTRY 266:20283-20289(1991).
