INPP5B
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Official Full Name
inositol polyphosphate-5-phosphatase, 75kDa -
Overview
Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. -
Synonyms
INPP5B;inositol polyphosphate-5-phosphatase, 75kDa;inositol polyphosphate 5 phosphatase, 75kD;type II inositol-1,4,5-trisphosphate 5-phosphatase;4;5-trisphosphate 5-phosphatase;5PTase;75 kDa inositol polyphosphate 5 phosphatase;75 kDa inositol polyphosphate-5-phosphatase;75kDa;EC 3.1.3.36;I5P2_HUMAN;Inositol polyphosphate 5-phosphatase II;Inositol polyphosphate-5-phosphatase B;Inpp5b protein;INPP5P;MGC65156;MGC71303;OTTHUMP00000004726;OTTHUMP00000004727;OTTHUMP00000004728;Phosphoinositide 5 phosphatase;Phosphoinositide 5-phosphatase;Type II inositol 1,4,5 trisphosphate 5 phosphatase;Type II inositol-1
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- Mammalian Cells
- In Vitro Cell Free System
- HEK293
- Non
- His
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| INPP5B-27623TH | Recombinant Human INPP5B | Wheat Germ | Human | Non | 748 amino acids |
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| INPP5B-8226M | Recombinant Mouse INPP5B Protein | Mammalian Cells | Mouse | His |
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| INPP5B-861HCL | Recombinant Human INPP5B cell lysate | Human | Non |
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| INPP5B-258HF | Recombinant Full Length Human INPP5B Protein | In Vitro Cell Free System | Human | Full L. 748 amino acids |
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| INPP5B-4556M | Recombinant Mouse INPP5B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| INPP5B-4556M-B | Recombinant Mouse INPP5B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| INPP5B-5106H | Recombinant Human INPP5B Protein, GST-tagged | Wheat Germ | Human | GST |
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| INPP5B-5954HF | Recombinant Full Length Human INPP5B Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 748 amino acids |
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Involved Pathway
INPP5B involved in several pathways and played different roles in them. We selected most pathways INPP5B participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | NOS2,UROS,GCNT2,MPST,AGXT,FUT8A,GBA,ATP5F1,ENO3,ATP6V0A2 |
| Inositol phosphate metabolism | PIP5K1BB,PIP5K1AB,INPP5K,PLCD1B,PLCH2,PIP4K2AA,INPP5J,PIK3CA,PIK3C2A,PIK3CB |
| Phosphatidylinositol signaling system | PI4KB,INPP4AB,PIK3C2G,INPP4A,SYNJ1,OCRL,PIP4K2B,PLCZ1,PI4K2A,PIP4K2A |
Protein Function
INPP5B has several biochemical functions, for example, inositol-1,4,5-trisphosphate 5-phosphatase activity,metal ion binding,phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5B itself. We selected most functions INPP5B had, and list some proteins which have the same functions with INPP5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | PRKD3,ZFP770,HPDA,TSSK1,TRMT44,ZNF493,UNC13A,ATP1A1A.1,CYP2A12,THAP5 |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | PTPMT1,INPP5E,OCRL,SYNJ2,EPM2A |
| inositol-1,4,5-trisphosphate 5-phosphatase activity | INPP5K,INPP5A,INPP5J |
| protein binding | RBM8A,ZBTB26,Mill2,TTC5,SCG5,FBXO32,SHC4,RGS2,FGF19,AP1G2 |
Interacting Protein
INPP5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5B here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5B.
Setdb1;Cbx4;RNASEH2A;Shoc2;KIF20A;FGFR1OP;Tuba3a;JUN;JAK3;Rmdn3;Clspn;Dync1li1;Cdc26;PARD6B;NUF2;DNAJC11
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References
- Sarantis, H; Balkin, DM; et al. Yersinia Entry into Host Cells Requires Rab5-Dependent Dephosphorylation of PI(4,5)P-2 and Membrane Scission. CELL HOST & MICROBE 11:117-128(2012).
