INPP5A
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Official Full Name
inositol polyphosphate-5-phosphatase, 40kDa -
Overview
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. -
Synonyms
INPP5A;inositol polyphosphate-5-phosphatase, 40kDa;inositol polyphosphate 5 phosphatase, 40kD;type I inositol-1,4,5-trisphosphate 5-phosphatase;5PTASE;43 kDa inositol polyphosphate 5 phophatase;CTCL tumor antigen HD CL 02;inositol polyphosphate 5 phophatase;40kDa;InsP3 5 phosphatase;type I inositol 1;4;5 trisphosphate 5 phosphatase;43 kDa inositol polyphosphate 5-phophatase;5-trisphosphate 5-phosphatase;CTCL tumor antigen HD-CL-02;DKFZp434A1721;I5P1;I5P1_HUMAN;Inositol polyphosphate 5 phosphatase;inositol polyphosphate-5-phosphatase A;inositol trisphosphate-5-phosphatase;INPP5A inositol polyphosphate-5-phosphatase;InsP3 5-phosphatase;MGC116947;MGC116949;Type I inositol-1;type I inositol-1,4,5-trisphosphate 5-phophatase;OTTHUMP00000020775;OTTHUMP00000020776;OTTHUMP00000020777;inositol trisphosphate-5-phosphatase, 40kD;type I inosito
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cells
- In Vitro Cell Free System
- His
- Non
- His&SUMO
- Myc&DDK
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| INPP5A-012H | Recombinant Human INPP5A Protein, His-tagged | E.coli | Human | His | 99-412 aa | |
| INPP5A-27622TH | Recombinant Human INPP5A | Wheat Germ | Human | Non | 100 amino acids |
|
| INPP5A-5199HCL | Recombinant Human INPP5A 293 Cell Lysate | HEK293 | Human | Non |
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| INPP5A-013H | Recombinant Human INPP5A Protein, His-tagged | HEK293 | Human | His | Met1-Val410 |
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| INPP5A-1012H | Recombinant Human INPP5A Protein (1-409 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-409 aa |
|
| INPP5A-3375H | Recombinant Human INPP5A Protein (Met1-Val410), C-His tagged | Mammalian Cells | Human | His | Met1-Val410 |
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| Inpp5a-3546M | Recombinant Mouse Inpp5a Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| INPP5A-3623H | Recombinant Human INPP5A Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| INPP5A-5108H | Recombinant Human INPP5A Protein, GST-tagged | Wheat Germ | Human | GST |
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| INPP5A-5953HF | Recombinant Full Length Human INPP5A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 412 amino acids |
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Involved Pathway
INPP5A involved in several pathways and played different roles in them. We selected most pathways INPP5A participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | INPP5D,PIP5K1AA,PI4K2A,PIP5K1BB,INPP1,TPI1,INPP4B,PIK3CB,PLCD1B,PTENB |
| Phosphatidylinositol signaling system | INPPL1,PLCD1A,PIP5K1AB,PIKFYVE,PIP5K1BB,PIK3R5,PIP5K1BA,PLCD4,PIK3CD,MTMR7B |
| Metabolic pathways | ACSL1B,EXT1B,LASS4,AKR1B1,AOX3L1,TSTA3,G6PD,GALNT11,HAO1,SAT2B |
Protein Function
INPP5A has several biochemical functions, for example, PH domain binding,inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity,inositol-1,4,5-trisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5A itself. We selected most functions INPP5A had, and list some proteins which have the same functions with INPP5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PH domain binding | EPB41L2,EPHA4 |
| protein binding | CLOCK,TNS1,CPSF6,EIF4EBP3L,GTF3C5,HTRA2,NARG2,AURKB,PSMB9,NFS1 |
| inositol-1,4,5-trisphosphate 5-phosphatase activity | INPP5J,INPP5K,INPP5B |
| inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity | INPP5K,INPP5J |
| inositol-polyphosphate 5-phosphatase activity | INPPL1,INPP5E,INPP5K,INPP5D,INPP5J |
Interacting Protein
INPP5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5A here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5A.
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References
- Kasumu, AW; Liang, X; et al. Chronic Suppression of Inositol 1,4,5-Triphosphate Receptor-Mediated Calcium Signaling in Cerebellar Purkinje Cells Alleviates Pathological Phenotype in Spinocerebellar Ataxia 2 Mice. JOURNAL OF NEUROSCIENCE 32:12786-12796(2012).
- Milinkovic, V; Bankovic, J; et al. Identification of Novel Genetic Alterations in Samples of Malignant Glioma Patients. PLOS ONE 8:-(2013).
