INPP4A
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Official Full Name
inositol polyphosphate-4-phosphatase, type I, 107kDa -
Overview
This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. -
Synonyms
INPP4A;inositol polyphosphate-4-phosphatase, type I, 107kDa;inositol polyphosphate 4 phosphatase, type I, 107kD , INPP4;type I inositol 3,4-bisphosphate 4-phosphatase;type I inositol-3,4-bisphosphate 4-phosphatase;INPP4;TVAS1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- His&T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
INPP4A involved in several pathways and played different roles in them. We selected most pathways INPP4A participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PLD4,IMPA1,TPI1,MINPP1,PIK3C2G,MTMR1,ITPK1A,PIKFYVE,ITPK1,PLCB2 |
| Metabolic pathways | MDH1,ENPP1,OXSM,ALAD,ARG1,GNE,PNLIPRP1,SGMS2,ST3GAL1,P4HA1B |
| Phosphatidylinositol signaling system | PIP5K1BB,IP6K3,PI4K2B,PI4KA,PLCD3A,IPPK,PIK3C2A,INPPL1A,MTMR1A,PLCB4 |
Protein Function
INPP4A has several biochemical functions, for example, phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity,phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP4A itself. We selected most functions INPP4A had, and list some proteins which have the same functions with INPP4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity | INPP4B |
| phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity | TMEM55A,TMEM55B,INPP4B |
Interacting Protein
INPP4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP4A here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP4A.
SMAD1
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References
- Sheffer, R; Bennett-Back, O; et al. Hindbrain malformation and myoclonic seizures associated with a deleterious mutation in the INPP4A gene. NEUROGENETICS 16:23-26(2015).
- Edea, Z; Dadi, H; et al. Linkage disequilibrium and genomic scan to detect selective loci in cattle populations adapted to different ecological conditions in Ethiopia. JOURNAL OF ANIMAL BREEDING AND GENETICS 131:358-366(2014).
