INHBC
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Official Full Name
inhibin, beta C -
Overview
This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types. -
Synonyms
INHBC;inhibin, beta C;inhibin beta C chain;Activin beta C chain;IHBC;OTTHUMP00000242576;activin beta-C chain
Recombinant Proteins
- Human
- Rat
- Mouse
- HEK293
- E.coli
- Mammalian Cells
- CHO
- Human Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- DDK&Myc
- Avi&Fc&His
- GST
Involved Pathway
INHBC involved in several pathways and played different roles in them. We selected most pathways INHBC participated on our site, such as Cytokine-cytokine receptor interaction,TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with INHBC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | Il23a,IL21R.1,Ifna15,TNFRSF1A,IFNA8,TGFB1,CXCR1,IL18RAP,CSF2RA,GH1 |
| Signaling pathways regulating pluripotency of stem cells | POU5F1,ESRRB,FGFR2,APC,RAF1,ACVR1,FZD6,BMI1,GRB2,NEUROG1 |
| TGF-beta signaling pathway | ID1,THBS1,NODAL,TGFB1,BMP8B,BMP4,RHOAC,MYCB,GDF6A,TGFBR1 |
Protein Function
INHBC has several biochemical functions, for example, cytokine activity,growth factor activity,hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INHBC itself. We selected most functions INHBC had, and list some proteins which have the same functions with INHBC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IL32,RNF207B,TNFSF14,THPO,IL3,IFNB,INHBE,MSTNA,IFNPHI3,IL1A |
| growth factor activity | PDGFD,FGF3,HDGF,BMP6,FGF20A,AMBN,CTGF,PSPN,GDF10B,PGF |
| transforming growth factor beta receptor binding | MSTNB,NODAL,TGFBR3,LRG1,INHBA,FKBP1A,GDF10B,MSTN,MSTNA,BMP3 |
| hormone activity | PRL3B1,IGF2B,TSHB,INS-IGF2,CSH2,PRL2C2,RETN,EPO,SCT,SST3 |
Interacting Protein
INHBC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INHBC here. Most of them are supplied by our site. Hope this information will be useful for your research of INHBC.
Resources
Research Area
Early Mesodermal Lineage MarkersEctodermal Lineage Markers
Mesodermal Lineage Markers
Activins
Activins / Inhibins
Related Services
Related Products
References
- Han, XF; Gu, LJ; et al. Effect of immunization against GnRH on hypothalamic and testicular function in rams. THERIOGENOLOGY 83:642-649(2015).
- Marino, FE; Risbridger, G; et al. The inhibin/activin signalling pathway in human gonadal and adrenal cancers. MOLECULAR HUMAN REPRODUCTION 20:1223-1237(2014).
