ING4
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Official Full Name
inhibitor of growth family, member 4 -
Overview
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. -
Synonyms
ING4;inhibitor of growth family, member 4;inhibitor of growth protein 4;my036;p29ING4;brain my036 protein;candidate tumor suppressor p33 ING1 homolog;MGC12557
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&Fc
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- GST
Involved Pathway
ING4 involved in several pathways and played different roles in them. We selected most pathways ING4 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ING4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | ACTL6A,SUZ12,PRMT7,SETD3,RBB4L,KDM2B,TADA1,KDM5BB,ENY2,SMARCD3 |
| Chromatin modifying enzymes | PADI2,SMARCB1A,TADA2B,ARID5B,KAT6B,GATAD2A,SMARCA4,RBBP4,PHF8,KAT5 |
| HATs acetylate histones | SAP130,DMAP1,PHF15,KAT7A,MEAF6,CCDC101,BRPF1,TAF6L,TADA2B,MSL2 |
Protein Function
ING4 has several biochemical functions, for example, methylated histone binding,protein binding,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ING4 itself. We selected most functions ING4 had, and list some proteins which have the same functions with ING4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | RNF14,MLL5,Ankar,ABRA,RARA,WWC1,HIF3A,GMEB2,CALCOCO1,DDX17 |
| methylated histone binding | ATRX,ING2,ING1,TDRD3,RAG2,TP53BP1,PHF13,UHRF1,KAT8,CHD8 |
| zinc ion binding | MYLIPB,KAT6A,NR2F1B,MLL5,ABLIM2,RFWD3,ZNF385B,RXRGB,TET1,APOBEC3G |
| protein binding | ACTR1B,FAM161A,NMNAT1,UBA5,AKAP8L,COPS2,KIF18B,GBP5,MBP,P2RX7 |
Interacting Protein
ING4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ING4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ING4.
HNRNPD;NAV2;HIST1H3D;HNRNPD;HNRNPD;HNRNPD;HNRNPD
Resources
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References
- Byron, SA; Min, E; et al. Negative Regulation of NF-kappa B by the ING4 Tumor Suppressor in Breast Cancer. PLOS ONE 7:-(2012).
