INCENP
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Official Full Name
inner centromere protein antigens 135/155kDa -
Overview
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding;centromere proteins and passenger, or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive;proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM;117142). The term passenger proteins encompasses a broad collection of proteins that localize to the centromere;during specific stages of the cell cycle (Earnshaw and Mackay, 1994 (PubMed 8088460)). These include CENPE (MIM;117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and;CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 (PubMed 1860899)), the;initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of;mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During;telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after;cytokinesis (Cutts et al., 1999 (PubMed 10369859)). -
Synonyms
INCENP;inner centromere protein antigens 135/155kDa;inner centromere protein antigens (135kD, 155kD);inner centromere protein;FLJ31633;chromosomal passenger protein;inner centromere protein INCENP;binds and activates aurora-B and -C in vivo and in
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| INCENP-6882C | Recombinant Chicken INCENP | Mammalian Cells | Chicken | His |
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| INCENP-7037H | Recombinant Human INCENP, His-tagged | Sf9 Cells | Human | His | 783 aa-end |
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| INCENP-8205M | Recombinant Mouse INCENP Protein | Mammalian Cells | Mouse | His |
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| INCENP-4541M | Recombinant Mouse INCENP Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| INCENP-4541M-B | Recombinant Mouse INCENP Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
INCENP involved in several pathways and played different roles in them. We selected most pathways INCENP participated on our site, such as Aurora B signaling,Aurora C signaling,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with INCENP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | USO1,NIPBLA,PMF1,ABL1,CUL1B,NUDC,YWHAQB,BRE,MAD1L1,TFDP2 |
| Cell Cycle, Mitotic | GINS2,CCP110,MCPH1,CEP78,ESCO2,SPDL1,NDEL1,NUPL2,NDE1,CENPN |
| Mitotic Metaphase and Anaphase | PMF1,CENPO,CLIP1,PDS5A,VRK2,MIS12,NDEL1A,CDCA8,CENPC1,CENPH |
| Aurora C signaling | AURKC,AURKB |
| Aurora B signaling | RACGAP1,SMC4,TACC1,SGOL1,NDC80,EVI5,NSUN2,CBX5,AURKB,KIF2C |
| Mitotic Prometaphase | ZW10,CENPC1,CENPL,MLF1IP,SKA1,CENPH,NDEL1,ERCC6L,NCAPG,CENPI |
| M Phase | ZW10,VRK2,SMC2,PHF8,NIPBL,STAG1,PDS5A,CNEP1R1,CENPN,SPC25 |
| Mitotic Anaphase | CENPN,ERCC6L,ANKLE2,PMF1,CENPP,CENPO,CLIP1,KNTC1,PDS5B,NUF2 |
Protein Function
INCENP has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INCENP itself. We selected most functions INCENP had, and list some proteins which have the same functions with INCENP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | WHSC1,ISG20L2,GPR125,DNALI1,FBXO44,PPM1A,KRTAP3-3,ACTL6A,RPL7,PARD6A |
Interacting Protein
INCENP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INCENP here. Most of them are supplied by our site. Hope this information will be useful for your research of INCENP.
BIRC5;AURKB;CBX5
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References
- Hamdouch, K; Rodriguez, C; et al. Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases. CLINICA CHIMICA ACTA 412:2267-2271(2011).
- Ohgami, H; Hiyoshi, M; et al. Xtr, a plural tudor domain-containing protein, is involved in the translational regulation of maternal mRNA during oocyte maturation in Xenopus laevis. DEVELOPMENT GROWTH & DIFFERENTIATION 54:660-671(2012).
