IKBKE
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Official Full Name
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon -
Overview
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling;pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed;in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 (PubMed 19481526)). -
Synonyms
IKBKE;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon;inhibitor of nuclear factor kappa-B kinase subunit epsilon;IKK i;IKKE;KIAA0151;IKK-epsilon;I-kappa-B kinase epsilon;inducible IkappaB kinase;IKK-related kinase epsilon;inducible I kappa-B kinase;IKKI;IKK-E;IKK-i;MGC125294;MGC125295;MGC125297
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Sf9 Insect Cell
- HEK293
- Mammalian Cell
- Insect Cell
- HEK293T
- Insect (sf21)
- GST
- Myc&DDK
- His
- Non
- His&Fc&Avi
Involved Pathway
IKBKE involved in several pathways and played different roles in them. We selected most pathways IKBKE participated on our site, such as Toll-like receptor signaling pathway,RIG-I-like receptor signaling pathway,Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RIG-I-like receptor signaling pathway | RNF125,IRF7,DAK,IFNB1,TNF,Ifna11,TRADD,IFNA6,DDX3X,IL8L1 |
| Measles | CD3E; CD3D,TNFRSF10A,CD3E,MAP3K7,IL2RB,IL2RA,EIF2AK3,SH2D1A,EIF2AK2,HSPA1B |
| Hepatitis C | IFNA10,BRAF,CLDN8,CLDN16,RAF1,NFKBIA,TNF,CLDN5,PIK3CD,STAT2 |
| Hepatitis B | RB1,HSPG2,NFATC3,PIK3CB,TRP53,STAT4,AKT1,SMAD4,IFNB1,AKT2 |
| Influenza A | PRKCB,IL33,HLA-DOB,MAPK12,IFNG,CXCL8,CYCS,TLR7,STAT1,PIK3CB |
| Cytosolic DNA-sensing pathway | NFKB1,IFNA8,POLR2L,IFNB1,OSTN,IL1B,POLR1D,IFNPHI3,POLR2F,POLR2H |
| Herpes simplex infection | SFRS9,HLA-DQA1,PTPN11A,BF1,IFNPHI1,MAPK8B,HLA-DRA,TRAF5,IL12A,HLA-DOA |
| Toll-like receptor signaling pathway | Ifna11,NFKB1,MAPK13,IFNAR1,MAPK9,MAPK8B,IFNA12,MAPK14B,PIK3R3B,IFNA1 |
Protein Function
IKBKE has several biochemical functions, for example, ATP binding,IkappaB kinase activity,K48-linked polyubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKE itself. We selected most functions IKBKE had, and list some proteins which have the same functions with IKBKE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CEP57,FBN1,KXD1,MLF2,HIST1H4E,FXYD6,BAI3,ZNF460,GORAB,TTC25 |
| IkappaB kinase activity | IKBKB,CHUK |
| ATP binding | PFKMB,TEC,ACOT12,GALK2,DDX19,MVDA,MAPK13,PAN3,UBE2G1B,MCM8 |
| NF-kappaB-inducing kinase activity | PPP4C,IRAK1,ALK,MAP3K14,RIPK3,ALPK2 |
| ubiquitin protein ligase binding | TRAF1,RNF40,YOD1,XBP1,UBE2W,DAXX,MYOD1,UBE2B,BID,GABARAPL1 |
| K48-linked polyubiquitin binding | UBXN1,UFD1L,VCP |
Interacting Protein
IKBKE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKE here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKE.
TANK;CDC37;MAVS;TBKBP1;N/A;DDX3X
Resources
Research Area
Transcription Regulators in Endothelial CellsIntracellular Kinases in the Akt Pathway
IkB Kinase (IKK)
Negative Regulators of the Jak/STAT Pathway
Positive Regulators of the Jak/STAT Pathway
Natural Killer T (NKT) Cells
C-type Lectin Receptors
NOD-like Receptors and the Inflammasome
RIG-I-like Receptors
IL-1 Family Signaling Molecules
IL-17 Signaling Related Molecules
Related Services
Related Products
References
