IKBKAP

  • Official Full Name

    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

  • Overview

    IKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKa, IKK?, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation.

  • Synonyms

    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein;IKBKAP;FD;DYS;ELP1;IKAP;IKI3;TOT1;FLJ12497;DKFZp781H1425;elongator complex protein 1;p150;OTTHUMP00000021869;IKK complex-associated protein;ikappaB kinase complex-associated protein

Recombinant Proteins

  • Rat
  • Human
  • Mouse
  • Mammalian Cells
  • HEK293
  • His
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
IKBKAP-3021R Recombinant Rat IKBKAP Protein Mammalian Cells Rat His
IKBKAP-497H Recombinant Human IKBKAP Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
IKBKAP-8100M Recombinant Mouse IKBKAP Protein Mammalian Cells Mouse His
IKBKAP-2676R Recombinant Rat IKBKAP Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
IKBKAP-2676R-B Recombinant Rat IKBKAP Protein Pre-coupled Magnetic Beads HEK293 Rat
IKBKAP-4485M Recombinant Mouse IKBKAP Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
IKBKAP-4485M-B Recombinant Mouse IKBKAP Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    IKBKAP involved in several pathways and played different roles in them. We selected most pathways IKBKAP participated on our site, such as IL-1 Signaling Pathway,TNF-alpha NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    IL-1 Signaling Pathway IL1RN,SIRPA
    TNF-alpha NF-kB Signaling Pathway SMARCC1,CASP8AP2,ZFAND5A,TRAF4A,SMARCB1A,CAPN3A,MTIF2,NLRP4E,SMARCA4A,TRPC4APA

    Protein Function

    IKBKAP has several biochemical functions, for example, ATP binding,contributes_to RNA polymerase II core binding,phosphorylase kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKAP itself. We selected most functions IKBKAP had, and list some proteins which have the same functions with IKBKAP. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to RNA polymerase II core binding ELP3,ELP4,ELP2
    ATP binding DDX59,PRKCBB,PRKACBA,PPIP5K2,MKNK2,ABCB11,THG1L,BMPR2B,PAK1,TGFBR2
    phosphorylase kinase regulator activity ELP3,PRKAG2,ELP4
    protein kinase activity INSRA,PLK5,MAP3K2,SBK1,LIMK1,TAOK1,MAPK14B,SRPK1A,CAMK2B1,PRKD2

    Interacting Protein

    IKBKAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKAP here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKAP.

    Ywhae

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