IKBIP
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Official Full Name
IKBKB interacting protein -
Overview
IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. Its activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-κB. Activated IKK-β phosphorylates a protein called the inhibitor of NF-κB, IκB (IκBα), which binds NF-κB to inhibit its function. Phosphorylated IκB is degraded via the ubiquitination pathway, freeing NF-κB, and allowing its entry into the nucleus of the cell where it activates various genes involved in inflammation and other immune responses. -
Synonyms
IKBIP;IKBKB interacting protein;inhibitor of nuclear factor kappa-B kinase-interacting protein;FLJ31051;I kappa B kinase interacting protein;IKIP;IKK interacting protein;IKK-interacting protein;IKBKB-interacting protein;i kappa-B kinase-interacti
Recombinant Proteins
- Human
- Mouse
- Rat
- Mus musculus
- Bovine
- E.coli
- Mammalian Cells
- HEK293
- His&T7
- His
- Myc&DDK
- Non
- His&Fc&Avi
Involved Pathway
IKBIP involved in several pathways and played different roles in them. We selected most pathways IKBIP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
IKBIP has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBIP itself. We selected most functions IKBIP had, and list some proteins which have the same functions with IKBIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DPEP1,KATNA1,LSM8,FAM108A1,WDR48,STAU1,SEMA7A,ZNF830,TLE2,HAPLN2 |
Interacting Protein
IKBIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBIP here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBIP.
MYOG;KRT15;NUP62;TPM3;C9orf16;TFIP11;Cep55;Ikbip
Resources
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References
- Hennig, EE; Mikula, M; et al. Extracellular matrix and cytochrome P450 gene expression can distinguish steatohepatitis from steatosis in mice. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:1762-1772(2014).
- Khattak, NA; Mir, A; et al. Computational Analysis of TRAPPC9: Candidate Gene for Autosomal Recessive Non-Syndromic Mental Retardation. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS 13:699-711(2014).
- Cen, H; Zhou, M; et al. Genetic interaction between genes involved in NF-kappa B signaling pathway in systemic lupus erythematosus. MOLECULAR IMMUNOLOGY 56:643-648(2013).
