Ihh
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Official Full Name
indian hedgehog -
Overview
This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Feb 2010] -
Synonyms
IHH;indian hedgehog;BDA1;HHG2;indian hedgehog protein;HHG-2;Indian hedgehog homolog
Recombinant Proteins
- Mouse
- Chicken
- Human
- Human/Mouse
- E.coli
- Mammalian Cells
- Non
- His
- T7
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Ihh-1892M |
Active Recombinant Mouse Indian Hedgehog
|
E.coli | Mouse | Non | 28-202 a.a. |
|
| IHH-6516C | Recombinant Chicken IHH | Mammalian Cells | Chicken | His |
|
|
| IHH-656H | Recombinant Human IHH protein | E.coli | Human | Non | 176 |
|
| IHH-7884H | Recombinant Human IHH protein, His-tagged | E.coli | Human | His | Phe240~Gly399 |
|
| IHH-124H | Recombinant Human/Mouse IHH Protein | E.coli | Human/Mouse |
|
||
| IHH-125H | Recombinant Human/Mouse IHH Protein | E.coli | Human/Mouse |
|
||
| IHH-126H | Recombinant Human/Mouse IHH Protein | E.coli | Human/Mouse |
|
||
| IHH-1673H | Recombinant Human IHH protein, His & T7-tagged | E.coli | Human | His&T7 | Val45~Ser195 |
|
| IHH-3104H | Recombinant Human IHH Protein (Phe240-Gly399), His tagged | E.coli | Human | His | Phe240-Gly399 |
|
| IHH-372I | Active Recombinant Human IHH Protein (178 aa) | E.coli | Human | 178 |
|
|
| IHH-433C | Recombinant Chicken IHH protein, His&Myc-tagged | E.coli | Chicken | His&Myc | 24-408a.a. |
|
| IHH-4428H | Recombinant Human IHH protein, His-tagged | E.coli | Human | His | 203-411aa |
|
Involved Pathway
Ihh involved in several pathways and played different roles in them. We selected most pathways Ihh participated on our site, such as Hedgehog signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ihh were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hedgehog signaling pathway | IHHB,DYRK1AA,ZIC2B,WNT2BB,SMO,WNT3,SAP18,WNT2BA,CSNK1DA,WNT3A |
Protein Function
Ihh has several biochemical functions, for example, calcium ion binding,patched binding,peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ihh itself. We selected most functions Ihh had, and list some proteins which have the same functions with Ihh. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptidase activity | PCSK7,OTUD4,CLPP,CAPN2B,PM20D1.1,ADAMTS16,C6AST3,FURINA,USP9,SPINT1A |
| calcium ion binding | HSPA5,ITGB1BP2,CANX,DSG2,NKD2B,PKD1L2,TTN,GSNB,MYL12.2,CDH17 |
| patched binding | SETD6,SMO,CAV1,DHH,Shh,PTCH1,BBS1,CCNB1 |
Interacting Protein
Ihh has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ihh here. Most of them are supplied by our site. Hope this information will be useful for your research of Ihh.
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References
- Kebenko, M; Drenckhan, A; et al. ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts. CELLULAR SIGNALLING 27:373-381(2015).
- Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).
