IGSF8
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Official Full Name
immunoglobulin superfamily, member 8 -
Overview
This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] -
Synonyms
IGSF8;immunoglobulin superfamily, member 8;EWI2;PGRL;CD316;EWI-2;KCT-4;CD81P3;LIR-D1;immunoglobulin superfamily member 8;CD81 partner 3;prostaglandin regulatory-like protein;glu-Trp-Ile EWI motif-containing protein 2;keratinocytes-associated transmembrane protein 4
Recombinant Proteins
- Human
- Cynomolgus
- Zebrafish
- Mouse
- E.coli
- Human Cells
- Mammalian Cells
- HEK293
- His
- Fc
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IGSF8-14128H | Recombinant Human IGSF8, His-tagged | E.coli | Human | His | 20-350a.a. | |
| IGFBP5-151C | Recombinant Cynomolgus IGSF8, His tagged | Human Cells | Cynomolgus | His | 1-271 a.a. |
|
| IGSF8-11826Z | Recombinant Zebrafish IGSF8 | Mammalian Cells | Zebrafish | His |
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| IGSF8-29100TH | Recombinant Human IGSF8, His-tagged | E.coli | Human | His | 185-613 a.a. |
|
| IGSF8-312H | Recombinant Human IGSF8, His tagged | Human Cells | Human | Fc | 1-579 a.a. |
|
| IGSF8-500H | Recombinant Human IGSF8 Protein, His-tagged | HEK293 | Human | His |
|
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| Igsf8-8697M | Recombinant Mouse IGSF8 protein(Met1-Thr577), His-tagged | HEK293 | Mouse | His | 1-577 a.a. |
|
| IGSF8-953M | Recombinant Mouse IGSF8 Protein, Fc-tagged | HEK293 | Mouse | Fc | 1-577 a.a. |
|
| IGSF8-1378MCL | Recombinant Mouse IGSF8 cell lysate | Human Cells | Mouse | Non |
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| IGSF8-977HCL | Recombinant Human IGSF8 cell lysate | Human Cells | Human | Non |
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| IGSF8-2919H | Recombinant Human IGSF8 Protein (Arg28-Thr579), C-His tagged | Mammalian Cells | Human | His | Arg28-Thr579 |
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| IGSF8-311H | Recombinant Human IGSF8(Arg28-Thr579) Protein, C-Fc-tagged | HEK293 | Human | Fc | 28-579 a.a. |
|
| IGSF8-5321H | Recombinant Human IGSF8 protein(Met1-Thr579), His-tagged | HEK293 | Human | His | Met1-Thr579 |
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Involved Pathway
IGSF8 involved in several pathways and played different roles in them. We selected most pathways IGSF8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IGSF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
IGSF8 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGSF8 itself. We selected most functions IGSF8 had, and list some proteins which have the same functions with IGSF8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C10orf119,PPP1R12C,GSDMA2,KLF2,POLDIP2,P2RX4,NPHP3,PPIB,ERP44,CTF1 |
Interacting Protein
IGSF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGSF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGSF8.
KRTAP10-4;KRTAP10-7;KRTAP10-8;KRTAP10-9;CD9
Resources
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References
- Rappa, G; Green, TM; et al. The Nuclear Pool of Tetraspanin CD9 Contributes to Mitotic Processes in Human Breast Carcinoma. MOLECULAR CANCER RESEARCH 12:1840-1850(2014).
- Glazar, AI; Evans, JP; et al. Immunoglobulin superfamily member IgSF8 (EWI-2) and CD9 in fertilisation: evidence of distinct functions for CD9 and a CD9-associated protein in mammalian sperm-egg interaction. REPRODUCTION FERTILITY AND DEVELOPMENT 21:293-303(2009).
- Murdoch, JN; Doudney, K; et al. Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia. MOLECULAR AND CELLULAR NEUROSCIENCE 22:62-74(2003).
