IGHMBP2
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Official Full Name
immunoglobulin mu binding protein 2 -
Overview
Immunoglobulin mu-binding protein 2 (IGHMBP2) is a nucleic acid binding protein that acts on both RNA and DNA. The mature protein contains an ATP-dependent RNA/DNA helicase domain, an R3H single-stranded nucleic acid-binding domain, and a zinc finger domain. Consistent with these multiple functional domains, in vitro data suggests this protein is involved in and array of cellular functions such as transcriptional activation, DNA replications immunoglobulin class switching, pre-mRNA splicing, and translation. -
Synonyms
IGHMBP2;immunoglobulin mu binding protein 2;DNA-binding protein SMUBP-2;cardiac transcription factor 1;CATF1;HCSA;HMN6;SMARD1;SMUBP2;GF-1;glial factor 1;ATP-dependent helicase IGHMBP2;immunoglobulin mu-binding protein 2;FLJ34220;FLJ41171
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IGHMBP2-01H | Recombinant Human IGHMBP2 Protein, His tagged | E.coli | Human | His | ||
| IGHMBP2-2843C | Recombinant Chicken IGHMBP2 | Mammalian Cells | Chicken | His |
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| IGHMBP2-3012R | Recombinant Rat IGHMBP2 Protein | Mammalian Cells | Rat | His |
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| IGHMBP2-4005Z | Recombinant Zebrafish IGHMBP2 | Mammalian Cells | Zebrafish | His |
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| IGHMBP2-5260HCL | Recombinant Human IGHMBP2 293 Cell Lysate | HEK293 | Human | Non |
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| IGHMBP2-2667R | Recombinant Rat IGHMBP2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| IGHMBP2-2667R-B | Recombinant Rat IGHMBP2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
IGHMBP2 involved in several pathways and played different roles in them. We selected most pathways IGHMBP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IGHMBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
IGHMBP2 has several biochemical functions, for example, ATP binding,ATP-dependent 5-3 DNA helicase activity,ATP-dependent 5-3 RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IGHMBP2 itself. We selected most functions IGHMBP2 had, and list some proteins which have the same functions with IGHMBP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TRIM59,TRAIP,TRIM41,ZDHHC15A,TXNDC17,ZFAND1,CYHR1,RNF38,GLI2,PRKCG |
| ATP-dependent 5-3 DNA helicase activity | NUDT19,RUVBL2,PIF1,HELB,DOM3Z |
| ATP binding | AMHR2,MCM6,MYH6,CLP1,ORC4L,RUNX3,TLK1A,MST1R,MYH10,PFKMB |
| transcription factor binding | CEBPG,ENPP2,STK36,YWHAZ,MYOCD,HYAL1,HTT,ZFPM2,MED25,NR0B2A |
| RNA-dependent ATPase activity | DDX39B,YTHDC2,DDX17 |
| single-stranded DNA binding | BLM,RPA4,SSBP3B,CSDA,RTF1,CDC45,LONP1,HNRNPA1,PURA,SSBP1 |
| tRNA binding | XPO5,EIF2AK4,MADD,TRMT1,SEPSECS,TRMU,KARS,FARSA,SSB,EARS2 |
| DNA helicase activity | RUVBL2,MCM2,MCM6L,FBXO18,INO80,MCM3,RECQL5,ATRX,DNA2,PIF1 |
| DNA-dependent ATPase activity | MSH6,RAD51D,RAD51B,SMARCAL1,MSH4,XRCC2,XRCC3,CDK7,RAD51L3,CHD6 |
Interacting Protein
IGHMBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGHMBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGHMBP2.
LSM8;HNRNPU;SASS6;SMC6;Kif19
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References
- Grohmann, K; Rossoll, W; et al. Characterization of Ighmbp2 in motor neurons and implications for the pathomechanism in a mouse model of human spinal muscular atrophy with respiratory distress type 1 (SMARD1). HUMAN MOLECULAR GENETICS 13:2031-2042(2004).
