Ighm
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Official Full Name
Immunoglobulin heavy constant mu -
Overview
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy;chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a;light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region;containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that;determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is;encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D);genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus;on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B;cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody;response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a;process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can;be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig;isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al.,;2005).
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IGHM-843HCL | Recombinant Human IGHM cell lysate | Human | Non |
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| IGHM-2284H | Recombinant Human IGHM Protein, His-tagged | E.coli | Human | His | Gly1-Tyr453 |
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Involved Pathway
Ighm involved in several pathways and played different roles in them. We selected most pathways Ighm participated on our site, such as Adaptive Immune System,Antigen activates B Cell Receptor (BCR) leading to generation of second messengers,B Cell Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ighm were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | BCL10,RAC3,CDK4,MAP2K2,SOS1,CR2,PIK3AP1,CD72,PIK3CD,CD22 |
| Immune System | SEC24A,GBP2,CFHL2,AP1G1,SIGLEC6,RNF19B,CFHL1,ASB18,CTSH,TLR6 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | BLK,PIK3AP1,AHCYL1,ITPR2,IGKV1-5,STIM1B,IGLC2,IGKC,AKR1C1,SRMS |
| Adaptive Immune System | LAIR2,SEC61B,CDKN1B,FGF18B,UBR1,LILRB3,ASB14,DYNC1I1,UBE2J2,DYNC1H1 |
| Signaling by the B Cell Receptor (BCR) | PIK3AP1,SRMS,STIM1B |
Protein Function
Ighm has several biochemical functions, for example, antigen binding,contributes_to immunoglobulin receptor binding,contributes_to peptidoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ighm itself. We selected most functions Ighm had, and list some proteins which have the same functions with Ighm. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PIP4K2B,FAM54A,RTN4RL2A,PENK,NDOR1,FBXL8,LCORL,ADH1A,PDS5A,VPS33B |
| contributes_to immunoglobulin receptor binding | IGJ |
| contributes_to peptidoglycan binding | IGJ |
| contributes_to phosphatidylcholine binding | IGJ |
| antigen binding | IL7R,LILRA3,LILRA1,CD40,TGFB1,FCN3,FCN2,LILRB4,IGKC,LCK |
| contributes_to single-stranded DNA binding | IGJ,PMS2,MSH3,POLR2D,MLH1,MSH2 |
Interacting Protein
Ighm has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ighm here. Most of them are supplied by our site. Hope this information will be useful for your research of Ighm.
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References
- Vollmers, C; Penland, L; et al. Novel Exons and Splice Variants in the Human Antibody Heavy Chain Identified by Single Cell and Single Molecule Sequencing. PLOS ONE 10:-(2015).
- Enders, A; Short, A; et al. Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:4513-4518(2014).
