IGF-II
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Official Full Name
Insulin-like Growth Factor-II -
Overview
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
IGF2;IGF-II;PP9974;C11orf43;insulin-like growth factor 2 (somatomedin A);insulin-like growth factor II;somatomedin-A;insulin-like growth factor type 2;GF2;FLJ22066;FLJ44734
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Involved Pathway
IGF-II involved in several pathways and played different roles in them. We selected most pathways IGF-II participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF-II were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
IGF-II has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by IGF-II itself. We selected most functions IGF-II had, and list some proteins which have the same functions with IGF-II. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
IGF-II has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF-II here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF-II.
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References
- Brandt, K; Grunler, J; et al. Effects of IGFBP-1 and IGFBP-2 and their fragments on migration and IGF-induced proliferation of human dermal fibroblasts. GROWTH HORMONE & IGF RESEARCH 25:34-40(2015).
- Iguchi, H; Nishina, T; et al. Phase I dose-escalation study evaluating safety, tolerability and pharmacokinetics of MEDI-573, a dual IGF-I/II neutralizing antibody, in Japanese patients with advanced solid tumours. INVESTIGATIONAL NEW DRUGS 33:194-200(2015).
