IFNB
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Official Full Name
interferon beta -
Overview
The IFN-β proteins are produced in large quantities by fibroblasts. They have antiviral activity that is involved mainly in innate immune response. Two types of IFN-β have been described, IFN-β1 (IFNB1) and IFN-β3 (IFNB3) (a gene designated IFN-β2 is actually IL-6). IFN-β1 is used as a treatment for multiple sclerosis as it reduces the relapse rate.IFN-β1 is not an appropriate treatment for patients with progressive, non-relapsing forms of multiple sclerosis. -
Synonyms
IFN-beta;interferon type B;interferon beta;IFNB;Azide Free
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IFNB-2207C | Recombinant Chicken IFNB protein, His-tagged | E.coli | Chicken | His | Ser27~Gln203 | |
| IFNB-55H |
Active Recombinant Human interferon-β
|
CHO | Human | Non |
|
|
| IFNB-2206C | Recombinant Chicken IFNB | Mammalian Cell | Chicken | His |
|
|
| IFNb-47M | Recombinant Mouse IFN beta | Yeast | Mouse | Non |
|
|
| IFNB-4671C | Recombinant Chicken IFNB protein, His-tagged | E.coli | Chicken | His | 28-203aa |
|
Involved Pathway
IFNB involved in several pathways and played different roles in them. We selected most pathways IFNB participated on our site, such as Cytokine-cytokine receptor interaction,Toll-like receptor signaling pathway,RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | PER2,BLA,ARNTL1A,SRPK1A,DDX58,TLR3,IFNA14,HLA-DRB3,NFKB1,HLA-DOB |
| Influenza A | TMPRSS13,EP300,IFNA14,DDX58,HLA-DQA2,IRF9,Ifna11,OAS2,RSAD2,IFN-a |
| RIG-I-like receptor signaling pathway | IFNA7,MAPK13,IFNA12,IKBKG,MAPK8A,RIPK1,OTUD5,IL12A,NFKBIAB,IFNA5 |
| Cytokine-cytokine receptor interaction | IL17RB,IL17A,IFNA6,IL6,TNFSF14,IFNG,CXCR1,KDR,CCL21B,CD70 |
| Jak-STAT signaling pathway | STAT2,STAT1,CRFB16,Gh,IFNAR2,IL2RGA,IL5RA,IFNA14,MYCB,CISH |
| Cytosolic DNA-sensing pathway | RELA,CCL5,POLR3GLB,Ifna11,IFNA8,POLR1C,IFNA5,POLR3E,IKBKE,CXCL10 |
| Toll-like receptor signaling pathway | NFKBIAA,IRAK4,MAP2K2,CCL4,MAP2K4A,IFNA7,TMED7-TICAM2,CXCL10,RIPK1,MYD88 |
Protein Function
IFNB has several biochemical functions, for example, cytokine activity,type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNB itself. We selected most functions IFNB had, and list some proteins which have the same functions with IFNB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| type I interferon receptor binding | OSTN,IFNE,IFNA2,GM13287,Ifna11,GM13278,GM13288,IFNPHI2,IFNA6,Gm13290 |
| cytokine activity | TGFB1A,INHBA,CMTM6,Il23a; Il12b,IL12BA,GPR19,SPAW,Ccl12,TNFB,TNFRSF11B |
Interacting Protein
IFNB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNB here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNB.
IFNB Related Signal Pathway
Resources
Related Services
Related Products
References
- Hara, K; Shirasuna, K; et al. Interferon-Tau Attenuates Uptake of Nanoparticles and Secretion of Interleukin-1 beta in Macrophages. PLOS ONE 9:-(2014).
- Kvistad, S; Myhr, KM; et al. Antibodies to Epstein-Barr virus and MRI disease activity in multiple sclerosis. MULTIPLE SCLEROSIS JOURNAL 20:1833-1840(2014).
