IFNA21

  • Official Full Name

    interferon, alpha 21

  • Overview

    This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus.

  • Synonyms

    IFNA21;interferon, alpha 21;interferon alpha-21;IFN alphaI;leukocyte interferon protein;Interferon alpha F;LeIF F;MGC126687;MGC126689;IFN-alpha-21;interferon alpha-F;leIF-F;IFN-alphaI

Recombinant Proteins

  • Human
  • E.coli
  • Spf Chicken Eggs
  • HEK293
  • Yeast
  • GST&His
  • Non
  • His
  • GST
  • DDK&Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
IFNA21-617H Recombinant Human IFNA21 Protein, His/GST-tagged E.coli Human GST&His Asp25~Glu189
IFNA21-140H Recombinant Human Interferon, Alpha 21 Spf Chicken Eggs Human Non
IFNA21-41H Recombinant Human Interferon, Alpha 21 E.coli Human Non
IFNA21-77H Recombinant Human Interferon, Alpha 21 E.coli Human Non
IFNA21-5280HCL Recombinant Human IFNA21 293 Cell Lysate HEK293 Human Non
IFNA21-076H Recombinant Human IFNA21 Protein E.coli Human 24-189 a.a.
IFNA21-1424H Recombinant Human IFNA21 Protein (24-189 aa), His-tagged Yeast Human His 24-189 aa
IFNA21-3069H Recombinant Human IFNA21 protein, His-tagged E.coli Human His 24-189aa
IFNA21-3100H Recombinant Human IFNA21 Protein (Asp25-Glu189), N-GST tagged E.coli Human GST Asp25-Glu189
IFNA21-6275H Recombinant Human IFNA21 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc

    Involved Pathway

    IFNA21 involved in several pathways and played different roles in them. We selected most pathways IFNA21 participated on our site, such as Cytokine-cytokine receptor interaction,Regulation of autophagy,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNA21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Natural killer cell mediated cytotoxicity BRAF,ITGAL,MAPK1,PTPN11,MAPK3,PPP3R1,SH3BP2,Casp3,RAET1G,IFNGR1
    Tuberculosis ITGB2L,ATP6V0B,PIK3C3,CD209A,CORO1A,MRC1,MRC2,ARHGEF12,TNFRSF1A,RFXANK
    Autoi CD28,HLA-DMA,HLA-DPB1,HLA-DRB5,TSHR,IFNA14,IFNA12,IFNA6,CD40,HLA-C
    ne thyroid disease Ifna15,HLA-DOB,PRF1,H2-AA,HLA-DPA1,HLA-E,TSHR,HLA-DPB1,CD86,HLA-C
    Influenza A IFNB,CASP9,NXF1,MAPK9,MAPK8,HNRNPUL1,TLR3,IFNA14,TLR7,CCL2
    Toll-like receptor signaling pathway CCL4L2,IL1B,IFNAR1,RAC1,MAPK12,STAT1A,CASP8,LBP,MAP2K4B,NFKBIAA
    RIG-I-like receptor signaling pathway IFNA2,IFNB1,IFNA7,IFIH1,IL8L2,DHX58,Ifna11,IKBKB,ISG15,IFNW1
    Jak-STAT signaling pathway SOCS4,PIK3CG,IL6ST,IFNA7,PTPN2A,STAT6,IL10RA,CISH,AKT2,PIAS4
    Cytosolic DNA-sensing pathway RELA,CXCL10,POLR1D,POLR3GL,IFNA5,IL6,IFNA7,IFNPHI1,POLR3H,AIM2

    Protein Function

    IFNA21 has several biochemical functions, for example, cytokine activity,cytokine receptor binding,type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNA21 itself. We selected most functions IFNA21 had, and list some proteins which have the same functions with IFNA21. You can find most of the proteins on our site.

    Function Related Protein
    type I interferon receptor binding IFNA8,IFNA6,IFNK,GM13278,IFNA14,GM13288,IFNA1,IFNPHI3,IFNA7,IFNPHI2
    cytokine receptor binding IFNA3,IL17C,IL17A/F3,Ifna11,IFNPHI1,MIF,IL15L,IFNPHI4,IL17B,IFNA14
    cytokine activity MSTNA,GDF6B,IFNA2,TNFSF14,NAMPT,VEGFA,CCL6,IFNB1,INHBB,IL8L2

    Interacting Protein

    IFNA21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNA21 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNA21.

    Resources

    References

    • Guo, YL; Gao, MC; et al. Molecular cloning and characterization of a novel bovine IFN-epsilon. GENE 558:25-30(2015).
    • Liu, R; Huang, DD; et al. Immunization with Recombinant SFTSV/NSs Protein Does Not Promote Virus Clearance in SFTSV-Infected C57BL/6J Mice. VIRAL IMMUNOLOGY 28:113-122(2015).

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