HYAL3
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Official Full Name
hyaluronoglucosaminidase 3 -
Overview
This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. -
Synonyms
HYAL3;hyaluronoglucosaminidase 3;hyaluronidase-3;LUCA 3;LUCA14;Minna14;Hyal-3;HYAL3_HUMAN;Hyaluronidase 3;Hyaluronoglucosaminidase-3;LUCA-3;LUCA3;Lung carcinoma protein 3;OTTHUMP00000211052;OTTHUMP00000211054;OTTHUMP00000219781
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HYAL3-14020H | Recombinant Human HYAL3, His-tagged | E.coli | Human | His | 1-350a.a. | |
| HYAL3-2976R | Recombinant Rat HYAL3 Protein | Mammalian Cell | Rat | His |
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| HYAL3-6839Z | Recombinant Zebrafish HYAL3 | Mammalian Cell | Zebrafish | His |
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| HYAL3-7954M | Recombinant Mouse HYAL3 Protein | Mammalian Cell | Mouse | His |
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| HYAL3-831HCL | Recombinant Human HYAL3 cell lysate | Human | Non |
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| HYAL3-2631R | Recombinant Rat HYAL3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| HYAL3-2631R-B | Recombinant Rat HYAL3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| HYAL3-4390M | Recombinant Mouse HYAL3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HYAL3-4390M-B | Recombinant Mouse HYAL3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| HYAL3-5220H | Recombinant Human HYAL3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HYAL3-5727HF | Recombinant Full Length Human HYAL3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 417 amino acids |
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Involved Pathway
HYAL3 involved in several pathways and played different roles in them. We selected most pathways HYAL3 participated on our site, such as Glycosaminoglycan degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYAL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | UGT2B7,ITPA,ACSS2L,POLR2F,SARDH,AKR1B1L,PGAM1B,PIK3C2G,ATIC,ALG10B |
| Glycosaminoglycan degradation | GUSB,NAGLU,HYAL1,GNS,SPAM1,HEXA,GALNS,HGSNAT,HYAL4,HPSE2 |
Protein Function
HYAL3 has several biochemical functions, for example, hyaluronoglucuronidase activity,hyalurononglucosaminidase activity,NOT hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HYAL3 itself. We selected most functions HYAL3 had, and list some proteins which have the same functions with HYAL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT hyalurononglucosaminidase activity | HYAL1,HYAL2 |
| hyaluronoglucuronidase activity | HYAL2 |
| protein binding | GAS1,SLC25A4,SMAD5,CEP76,MSH3,DIP2A,CIAO1,TSPAN15,ARFGAP3,HNRNPR |
| hyalurononglucosaminidase activity | CD44,KIAA1199,HYAL2,SPAM1,HYAL1,HYAL4,MGEA5,HYAL6 |
| NOT virus receptor activity | HYAL1 |
Interacting Protein
HYAL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYAL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYAL3.
DAB1;SLC22A2
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References
- Prando, ED; Cavalli, LR; et al. Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. EPIGENETICS 6:1413-1424(2011).
- Lokeshwar, VB; Schroeder, GL; et al. Regulation of hyaluronidase activity by alternative mRNA splicing. JOURNAL OF BIOLOGICAL CHEMISTRY 277:33654-33663(2002).
