HTRA2
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Official Full Name
HtrA serine peptidase 2 -
Overview
High temperature requirement protein A2 (HtrA2)/Omi is a serine protease with homology to the E. coli HtrA protein (DegP) and is thought to be involved in apoptosis and stress-induced degradation of misfolded proteins. While HtrA2 was orignally identified -
Synonyms
HTRA2;HtrA serine peptidase 2;protease, serine, 25 , PRSS25;serine protease HTRA2, mitochondrial;OMI;PARK13;serine protease 25;protease, serine, 25;serine proteinase OMI;HtrA-like serine protease;Omi stress-regulated endoprotease;high temperatu
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Drosophila persimilis (Fruit fly)
- Drosophila pseudoobscura pseudoobscura (Fruit fly)
- Drosophila yakuba (Fruit fly)
- Drosophila simulans (Fruit fly)
- Drosophila willistoni (Fruit fly)
- Bovine
- Drosophila virilis (Fruit fly)
- Drosophila erecta (Fruit fly)
- Drosophila mojavensis (Fruit fly)
- Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
- Drosophila ananassae (Fruit fly)
- Mus musculus
- Drosophila melanogaster (Fruit fly)
- Drosophila sechellia (Fruit fly)
- E.coli
- Mammalian Cells
- HEK293
- His
- Avi&Fc&His
- Non
Involved Pathway
HTRA2 involved in several pathways and played different roles in them. We selected most pathways HTRA2 participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTRA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | SNCAIP,NDUFS8,NDUFB1,GPR37,UBE2G1,CASP9,NDUFB8,ATP5H,COX6A2,NDUFB4 |
Protein Function
HTRA2 has several biochemical functions, for example, peptidase activity,protein binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTRA2 itself. We selected most functions HTRA2 had, and list some proteins which have the same functions with HTRA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | PREPL,PRSS21,PRSS48,TPSG1,PRSS33,FURIN,PRSS3,C1rb,LTF,PRSS46 |
| unfolded protein binding | HSPA6,ST13,TTC1,CALR3,PFDN2,CLN3,DNAJA3B,NPM1,SCG5,HSPA1L |
| peptidase activity | PSMB11,PRSS44,HM13,APH1C,Gzmd,PRSS28,PSMA6B,FOLH1,GZMC,USP43 |
| protein binding | ORC1L,UBE2Q1,RPLP0,CDK7,SERPING1,PJA1,CTTNBP2NL,GDNF,PIN1,USF1 |
| serine-type peptidase activity | PRSS48,KLK1B16,TPSAB1,C1RA,Gzmg,GZME,MCPT1,GZMB,TMPRSS11F,ZFYVE9 |
Interacting Protein
HTRA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTRA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HTRA2.
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References
- Suwannaboon, R; Phiwsaiya, K; et al. The identification and expression of the full-length HtrA2 gene from Penaeus monodon (black tiger shrimp). PROTEIN EXPRESSION AND PURIFICATION 92:183-189(2013).
- Oliveira, RDR; Fontana, V; et al. Differential Gene Expression Profiles May Differentiate Responder and Nonresponder Patients with Rheumatoid Arthritis for Methotrexate (MTX) Monotherapy and MTX plus Tumor Necrosis Factor Inhibitor Combined Therapy. JOURNAL OF RHEUMATOLOGY 39:1524-1532(2012).
