HSP27
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Official Full Name
Heat Shock Protein-27 -
Overview
Heat shock protein 27 (Hsp27) also known as heat shock protein beta-1 (HSPB1) is a protein that in humans is encoded by the HSPB1 gene. Hsp27 is a chaperone of the sHsp (small heat shock protein) group among ubiquitin, α-crystallin, Hsp20 and others. The common functions of sHsps are chaperone activity, thermotolerance, inhibition of apoptosis, regulation of cell development, and cell differentiation. They also take part in signal transduction. -
Synonyms
Heat shock 27kDa protein;Heat Shock Protein-27;28 kDa heat shock protein;CMT2F;DKFZp586P1322;Estrogen regulated 24 kDa protein;Estrogen-regulated 24 kDa protein;Heat shock 25kDa protein 1;Heat shock 27 kDa protein;Heat shock 27kDa protein 1;Heat shock 28kDa protein 1;Heat Shock Protein 27;Heat shock protein beta 1;Heat shock protein beta-1;Heat Shock Protein27;HMN2B;HS.76067;Hsp 25;Hsp 27;Hsp 28;Hsp B1;Hsp25;Hsp28;HspB1;SRP27;Stress responsive protein 27;Stress-responsive protein 27
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HSP27-13976H | Recombinant Human HSP27, GST-tagged | E.coli | Human | GST | 1-182a.a. |
Involved Pathway
HSP27 involved in several pathways and played different roles in them. We selected most pathways HSP27 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HSP27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HSP27 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by HSP27 itself. We selected most functions HSP27 had, and list some proteins which have the same functions with HSP27. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
HSP27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSP27 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSP27.
Resources
Research Area
Cancer Drug TargetsDiabetic Peripheral Neuropathy
Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway
Intracellular Signaling Molecules in Angiogenesis
Related Services
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References
- Chen, HF; Liu, SJ; et al. Heat shock protein 27 phosphorylation in the proliferation and apoptosis of human umbilical vein endothelial cells induced by high glucose through the phosphoinositide 3-kinase/Akt and extracellular signal-regulated kinase 1/2 pathways. MOLECULAR MEDICINE REPORTS 11:1504-1508(2015).
- Chen, P; Shi, LL; et al. Identification of heat shock protein 27 as a novel autoantigen of Behcet's disease. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 456:866-871(2015).
