HSD3B2
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Official Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 -
Synonyms
HSD3B2;hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2;3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2;SDR11E2;short chain dehydrogenase/reductase family 11E;member 2;3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2;3-beta-HSD II;3 beta-HSD type II;progesterone reductase;delta 5-delta 4-isomerase type II;3-beta-HSD adrenal and gonadal type;3-beta-hydroxy-5-ene steroid dehydrogenase;3-beta-hydroxy-Delta(5)-steroid dehydrogenase;short chain dehydrogenase/reductase family 11E, member 2;4-isomerase type II;3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II;HSDB;HSD3B
Recombinant Proteins
- Human
- Chicken
- Mouse
- Mus musculus
- Mesocricetus auratus
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- GST
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
HSD3B2 involved in several pathways and played different roles in them. We selected most pathways HSD3B2 participated on our site, such as Steroid hormone biosynthesis,Metabolic pathways,Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD3B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Steroid hormone biosynthesis | HSD17B12A,HSD3B5,UGT1A6A,UGT1A1,UGT2B7,CYP2C39,CYP2C70,HSD17B6,CYP3A41B,CYP2C38 |
| Metabolic pathways | MTR,AGPS,CERS1,ACSL4A,NDUFA12,HADHAB,ITPKC,ATP5A1,UROS,COX8C |
| Aldosterone synthesis and secretion | SLC14A2,NETO2,KCNK9,AGTR1,ITPR1,PLCB3,NR4A2,GNAS,CAMK2B,LIPE |
| Ovarian steroidogenesis | AKR1C3,INSR,FSHR,PRKACA,HSD3B1,GDF9,ALOX5,FSHB,PTGS2,PRKACG |
Protein Function
HSD3B2 has several biochemical functions, for example, 3-beta-hydroxy-delta5-steroid dehydrogenase activity,steroid delta-isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD3B2 itself. We selected most functions HSD3B2 had, and list some proteins which have the same functions with HSD3B2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-beta-hydroxy-delta5-steroid dehydrogenase activity | HSD3B7,HSD3B1,HSD3B6,NSDHL,HSD3B4,HSD3B5,SDR42E1 |
| steroid delta-isomerase activity | EBP,HSD3B1,HSD3B6 |
Interacting Protein
HSD3B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD3B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD3B2.
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References
- Doi, M; Satoh, F; et al. Isoform-Specific Monoclonal Antibodies Against 3 beta-Hydroxysteroid Dehydrogenase/Isomerase Family Provide Markers for Subclassification of Human Primary Aldosteronism. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E257-E262(2014).
- Li, MH; Wu, FR; et al. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. BIOLOGY OF REPRODUCTION 86:-(2012).
