HOXD8
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Official Full Name
homeobox D8 -
Overview
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5 end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants. -
Synonyms
HOXD8;homeobox D8;homeo box D8 , HOX4, HOX4E;homeobox protein Hox-D8;Homeobox protein Hox-4E;Homeobox protein Hox-5.4;Hox-4.5;Hox-4E;Hox-5.4;HOX4;HXD8_HUMAN;homeo box 4E;homeo box D8;OTTHUMP00000163337;OTTHUMP00000205236;OTTHUMP00000205237;homeobox protein 5.4;HOX4E;HOX5.4
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HOXD8-13915H | Recombinant Human HOXD8, His-tagged | E.coli | Human | His | 1-289a.a. | |
| HOXD8-26896TH | Recombinant Human HOXD8 | Wheat Germ | Human | Non | 65 amino acids |
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| HOXD8-4999H | Recombinant Human HOXD8 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HOXD8-7117C | Recombinant Chicken HOXD8 | Mammalian Cells | Chicken | His |
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| HOXD8-7820M | Recombinant Mouse HOXD8 Protein | Mammalian Cells | Mouse | His |
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| HOXD8-5410HCL | Recombinant Human HOXD8 293 Cell Lysate | HEK293 | Human | Non |
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| HOXD8-3737HF | Recombinant Full Length Human HOXD8 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 289 amino acids |
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| HOXD8-4300M | Recombinant Mouse HOXD8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HOXD8-4300M-B | Recombinant Mouse HOXD8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HOXD8 involved in several pathways and played different roles in them. We selected most pathways HOXD8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HOXD8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HOXD8 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXD8 itself. We selected most functions HOXD8 had, and list some proteins which have the same functions with HOXD8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | NME2,CREB3L3,BCL6,CGGBP1,ARID3A,E2F7,DMBX1,ZBTB4,ZNF561,ZFY1 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MYF5,PAX9,GABPA,CSRNP1,CTCF,CSRNP3,NKX2-5,NR1I2,GRHL3,NKX2 |
Interacting Protein
HOXD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXD8.
PFDN1;RCC1;ANXA7;CDKN1A;q9wmx2-pro_0000037541;q9wmx2-pro_0000037545;q9wmx2-pro_0000037547;q9wmx2-pro_0000037549;q9wmx2-pro_0000037552
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