HNRNPH2
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Official Full Name
heterogeneous nuclear ribonucleoprotein H2 (H) -
Overview
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. -
Synonyms
HNRNPH2;heterogeneous nuclear ribonucleoprotein H2 (H);HNRPH2;heterogeneous nuclear ribonucleoprotein H2;FTP3;hnRNPH;HNRPH;FTP-3;hnRNP H;hnRNP H2;heterogeneous nuclear ribonucleoprotein H-prime
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
Involved Pathway
HNRNPH2 involved in several pathways and played different roles in them. We selected most pathways HNRNPH2 participated on our site, such as Gene Expression,Processing of Capped Intron-Containing Pre-mRNA,mRNA Splicing, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA processing | RBM5,SF3A1,PRPF4B,ZFP346,RPL36A-HNRNPH2,HNRNPH1,PPM1G,SFSWAP,HNRNPH1L,RBM12B2 |
| mRNA Splicing - Major Pathway | PCBP2,HNRNPUL1,HNRPL,SF3B4,TXNL4A,PTBP1B,HNRNPA0B,SF3B2,HNRNPD,SUGP1 |
| mRNA Splicing | PTBP1B,HNRNPA0L,HNRNPD,PRPF8,HNRNPA0B,SF3A1,HNRNPH1L,DNAJC8,HNRPL,ZMAT5 |
| Processing of Capped Intron-Containing Pre-mRNA | CSTF1,PTBP1A,YBX1,HNRNPA0L,SF3B4,NXF1,HNRNPR,HNRNPA0,ZMAT5,RNPC3 |
| Gene Expression | TRMT44,ZNF454,SEC61B,TNRC6B,ZNF561,HELZ2,GTF3C5,ADAT1,PDCD7,ZNF684 |
Protein Function
HNRNPH2 has several biochemical functions, for example, RNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPH2 itself. We selected most functions HNRNPH2 had, and list some proteins which have the same functions with HNRNPH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | EIF3G,TUBA1L,RBMY1F,TAF15,CELF5,ACSM2,SRSF7,PABPC1L2A,PTK6B,ZCRB1 |
| protein binding | COX17,ELN,PSIP1,POLE3,CLIP4,UCHL1,LRP12,MALSU1,C1QTNF6,BAG1 |
| RNA binding | NSUN3,RBM18,QKI2,SRSF3,PAPOLB,CELF2,FMR1,ZNF385C,PPP5C,RBM14 |
| poly(A) RNA binding | EIF2S2,PRPF3,HIST1H4A,ELAVL2,HIST1H47,VCP,HIST1H4N,METAP2,CORO1A,RPL27A |
Interacting Protein
HNRNPH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPH2.
TEKT1;MSI2;HNRNPA0;Ybx1;YWHAZ;RBFOX2;PQBP1;HSPB1;SNRPC;DDX5;GNB2L1;RBM10;ILF3;RBM39
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