HLCS
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Official Full Name
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -
Overview
This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
HLCS;holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase);holocarboxylase synthetase (biotin (proprionyl Coenzyme A carboxylase (ATP hydrolysing)) ligase) , holocarboxylase synthetase (biotin [proprionyl Coenzyme A carboxylase (ATP hydrolysing)] ligase);biotin--protein ligase;HCS;Biotin [acetyl CoA carboxylase] ligase;Biotin [methylcrotonoyl CoA carboxylase] ligase;Biotin [methylmalonyl CoA carboxytransferase] ligase;Biotin [propionyl CoA carboxylase [ATP hydrolyzing]] ligase;Biotin apo protein ligase;Biotin apo-protein ligase;Biotin protein ligase;Biotin--[acetyl-CoA-carboxylase] ligase;BPL1_HUMAN;EC 6.3.4.-;Holocarboxylase synthetase;Holocarboxylase synthetase, EC 6.3.4;biotin--[methylcrotonoyl-CoA-carboxylase] ligase;biotin--[methylmalonyl-CoA-carboxytransferase] ligase;holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLCS-4850H | Recombinant Human HLCS Protein, GST-tagged | Wheat Germ | Human | GST |
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| HLCS-5491HCL | Recombinant Human HLCS 293 Cell Lysate | HEK293 | Human | Non |
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| HLCS-2244H | Recombinant Human HLCS Protein, His-tagged | E.coli | Human | His | Met1-Ser172 |
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| HLCS-3632HF | Recombinant Full Length Human HLCS Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 726 amino acids |
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| Hlcs-491M | Recombinant Mouse Hlcs Protein, MYC/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| HLCS-6636H | Recombinant Human HLCS Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
HLCS involved in several pathways and played different roles in them. We selected most pathways HLCS participated on our site, such as Biotin metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLCS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GLS,NT5C3A,IDO2,POLR2K,MECR,UGT5G1,DHCR24,HYAL4,NDUFAB1A,GSS |
| Biotin metabolism | BTD,OXSM |
Protein Function
HLCS has several biochemical functions, for example, ATP binding,biotin binding,biotin-[acetyl-CoA-carboxylase] ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLCS itself. We selected most functions HLCS had, and list some proteins which have the same functions with HLCS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CAMK1D,MYO15,CTPS1A,ATP5B,NLRP12,CHD4,PRKCG,HIPK2,AKT3,BMPR2 |
| biotin binding | PC,PCXB,AVR2,MCCC1,PCCA,PCXA |
| enzyme binding | TSPYL1,NPM2,CASP2,ZFHX3,BTG1,DAXX,BCL10,HAND1,PTPLAD1,SCNM1-PS |
| protein binding | WHRN,FAF2,KIF14,STX12,SYNCRIP,2610109H07Rik,KCNE4,GPR37L1,KIF18A,HIST1H4C |
| protein homodimerization activity | CADM4,ADSSL1,LHPP,UGT1A7,FAP,PVRL3B,TLR13,PDK2,TCF3,BHLHA15 |
Interacting Protein
HLCS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLCS here. Most of them are supplied by our site. Hope this information will be useful for your research of HLCS.
ACACB;POT1;SNX27;DDX52
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References
- Vosough, M; Omidinia, E; et al. Generation of Functional Hepatocyte-Like Cells from Human Pluripotent Stem Cells in a Scalable Suspension Culture. STEM CELLS AND DEVELOPMENT 22:2693-2705(2013).
